Characterization of the perceived sound of trauma-induced tinnitus in gerbils
Characterization of the perceived sound of trauma-induced tinnitus in gerbils
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DOI：
10.1121/1.3646902
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发表时间：
2011-11-01
影响因子：
2.4
通讯作者：
Gaese, Bernhard H.
中科院分区：
文献类型：
--
作者：
Nowotny, Manuela;Remus, Martina;Gaese, Bernhard H.
耳鸣通常是在内耳病变后发生的，比如听觉创伤。因此，利用调制的声惊厥反应建立了沙土鼠耳鸣的声创伤模型。用听性脑干反应(ABR)和失真产物耳声发射(DPOAE)评价暴露于10 kHz窄带噪声所致的耳蜗损伤。在10 khz的频率下，阈值漂移约为25分贝。声学惊吓反应范式记录了幻影噪声知觉的诱导。在行为水平上，GAP-Pre脉冲抑制声惊厥(GPIAS)的减少可作为耳鸣的证据。伤后3~5周，ABR、DPOAE阈值恢复正常。当时，在16-20 kHz的频率范围内，GPIA的降低表明存在幻影噪声感知。创伤后7周，耳鸣的影响频率范围变窄，并向中心创伤频率移动，频率为10 kHz。综上所述，通过详细研究频率依赖效应，这项研究在沙土鼠身上发现，创伤诱发耳鸣在与诱导噪音创伤的低频斜率接壤的频率范围内发展。这支持侧向抑制作为耳鸣的生理基础的理论。(C)2011年美国声学学会。[DOI：10.1121/1.3646902]
Tinnitus often develops following inner ear pathologies, like acoustic trauma. Therefore, an acoustic trauma model of tinnitus in gerbils was established using a modulated acoustic startle response. Cochlear trauma evoked by exposure to narrow-band noise at 10 kHz was assessed by auditory brainstem responses (ABR) and distortion product otoacoustic emissions (DPOAE). Threshold shift amounted to about 25 dB at frequencies > 10 kHz. Induction of a phantom-noise perception was documented by an acoustic startle response paradigm. A reduction of the gap-prepulse inhibition of acoustic startle (GPIAS) was taken as evidence for tinnitus at the behavioral level. Three to five weeks after trauma the ABR and DPOAE thresholds were back to normal. At that time, a reduction of GPIAS in the frequency range 16-20 kHz indicated a phantom noise perception. Seven weeks post trauma the tinnitus-affected frequency range became narrow and shifted to the center-trauma frequency at 10 kHz. Taken together, by investigating frequency-dependent effects in detail, this study in gerbils found trauma-evoked tinnitus developing in the frequency range bordering the low frequency slope of the induced noise trauma. This supports the theory of lateral inhibition as the physiological basis of tinnitus. (C) 2011 Acoustical Society of America. [DOI: 10.1121/1.3646902]