GRAFT-COPOLYMERS THAT EXHIBIT TEMPERATURE-INDUCED PHASE-TRANSITIONS OVER A WIDE-RANGE OF PH
GRAFT-COPOLYMERS THAT EXHIBIT TEMPERATURE-INDUCED PHASE-TRANSITIONS OVER A WIDE-RANGE OF PH
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DOI：
10.1038/373049a0
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发表时间：
1995-01-05
期刊：
影响因子：
64.8
通讯作者：
HOFFMAN, AS
中科院分区：
文献类型：
--
作者：
CHEN, GH;HOFFMAN, AS
在医学、生物技术、工业和环境问题方面，“智能”含水聚合物系统有许多潜在的应用（1-8）。这些聚合物体系中的许多经历可逆的相变-例如，体积的突然变化-响应于外部刺激，例如温度、pH或溶剂的性质。以前研究的大多数聚合物只对一种刺激有反应。但对于某些应用，可能需要对几个因素（如温度和pH值）的独立响应。在这里，我们描述了一种聚合物，在水中的溶解度发生显着变化，响应于温度和/或pH值的变化，该聚合物是通过接枝温度敏感的侧链到pH敏感的主链上制备的。我们还发现，嵌段共聚物，其中的温度和pH敏感的单元交替沿沿着链，表现出类似的行为。
THERE are many potential applications of 'intelligent' aqueous polymer systems(1-8) in medicine, biotechnology, industry and in environmental problems(9-13). Many of these polymer systems undergo reversible phase transitions-for example, abrupt changes in volume-in response to external stimuli such as temperature, pH or the nature of the solvent. Most of the polymers studied previously are responsive to only one kind of stimulus. But for some applications, independent responsiveness to several factors, such as temperature and pH, may be required. Here we describe a polymer that undergoes marked solubility changes in water in response to temperature and/or pH changes, The polymer is prepared by grafting temperature-sensitive side chains onto a pH-sensitive backbone, We also find that block copolymers, in which the temperature- and pH-sensitive units alternate along the chain, show similar behaviour.