Effect of orlistat alone or in combination with Garcinia cambogia on visceral adiposity index in obese patients.
Effect of orlistat alone or in combination with Garcinia cambogia on visceral adiposity index in obese patients.
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DOI：
10.5455/jice.20160815080732
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发表时间：
2016-09
期刊：
影响因子：
--
通讯作者：
Al-Gareeb AI
中科院分区：
文献类型：
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作者：
Al-Kuraishy HM;Al-Gareeb AI
本研究的目的是评价奥利司他单独及与藤黄合用对肥胖患者内脏脂肪指数(VAI)的影响。总共招募了99名肥胖男性患者，年龄在37岁到46岁之间。随机分为3组，第1组给予奥利司他120 mg/d，第2组给予藤黄166 mg/d，第3组给予奥利司他120 mg/d+藤黄166 mg/d。疗程为连续3个月。分别在基线和3个月后记录体重指数(BMI)、VAI、血压、血糖、总脂谱、动脉粥样硬化指数和心脏危险比。秋葵治疗可导致VAI P<；0.05降低，而奥利司他对心脏代谢谱有有益影响，但不会降低VAI P>；0.05。樟脑联合奥利司他治疗对VAI、P<；0.05、心脏代谢指标及人体测量指标P<；0.01的降低较治疗前更为显著。葛根素与奥利司他合用对改善肥胖患者的心脏代谢谱和VAI的作用明显优于单用奥利司他。
The objective of this study was to estimate the effect of orlistat alone and in combination with Garcinia cambogia on visceral adiposity index (VAI) in obese patients. A total of 99 obese male patients were recruited with aged range between 37 and 46 years. They were randomized into three equal groups, first group treated with orlistat 120 mg/day, second group treated with G. cambogia 166 mg/day, and third group treated with orlistat 120 mg/day plus G. cambogia 166 mg/day. The duration of the treatments was three consecutive months. Body mass index (BMI), VAI, blood pressure, blood glucose, total lipid profile, atherogenic index, and cardiac risk ratio were recorded at baseline and after 3 months. The treatment with G. cambogia leads to reduction in VAI P < 0.05, whereas orlistat has a beneficial effect on cardiometabolic profiles without a reduction in VAI P > 0.05. Combined therapy of G. cambogia plus orlistat showed the more significant effect in reduction of VAI P < 0.05, cardiometabolic profiles and anthropometric measures P < 0.01 compared to pretreatment period. Combination of G. cambogia with orlistat lead to more significant effect than orlistat alone in amelioration of cardiometabolic profile and VAI in obese patients.