Bacterial programmed cell death and multicellular behavior in bacteria.
Bacterial programmed cell death and multicellular behavior in bacteria.
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细菌程序性细胞死亡和细菌多细胞行为。
DOI：
10.1371/journal.pgen.0020135
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发表时间：
2006-10
期刊：
影响因子：
4.5
通讯作者：
中科院分区：
文献类型：
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作者：
传统上，程序性细胞死亡（PCD）与真核多细胞生物有关。然而，最近在细菌中也观察到了PCD系统。在这里，我们回顾了最近的两种基因程序，促进细菌细胞死亡的研究。第一种是由MazEF介导的，MazEF是一种存在于多种细菌染色体中的毒素-抗毒素模块，主要在大肠杆菌中进行研究。第二个程序在枯草芽孢杆菌中发现，其中skf和sdp操纵子介导形成孢子的细菌细胞亚群的死亡。我们将这两种细菌PCD系统与细菌种群类似于多细胞生物的方式联系起来。
Traditionally, programmed cell death (PCD) is associated with eukaryotic multicellular organisms. However, recently, PCD systems have also been observed in bacteria. Here we review recent research on two kinds of genetic programs that promote bacterial cell death. The first is mediated by mazEF, a toxin–antitoxin module found in the chromosomes of many kinds of bacteria, and mainly studied in Escherichia coli. The second program is found in Bacillus subtilis, in which the skf and sdp operons mediate the death of a subpopulation of sporulating bacterial cells. We relate these two bacterial PCD systems to the ways in which bacterial populations resemble multicellular organisms.