TET Methylcytosine Oxidases in T Cell and B Cell Development and Function.
TET Methylcytosine Oxidases in T Cell and B Cell Development and Function.
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DOI：
10.3389/fimmu.2017.00220
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发表时间：
2017
影响因子：
7.3
通讯作者：
Rao A
中科院分区：
文献类型：
--
作者：
Tsagaratou A;Lio CJ;Yue X;Rao A
DNA甲基化是由DNA甲基转移酶建立的，是一个关键的表观遗传标记。Tet蛋白是一种将5-甲基胞嘧啶(5mC)氧化为5-羟甲基胞嘧啶(5hmC)并进一步氧化产物(oxi-MCS)的酶，间接促进DNA去甲基化。在这里，我们提供了Tet蛋白和DNA修饰状态改变在T和B细胞发育和功能中的作用的概述。我们综述了目前对Tet蛋白和5HmC在T和B细胞中在生理和病理环境中的作用的理解进展。我们描述了Tet蛋白和5hmC如何调控DNA修饰、染色质可及性、基因表达和转录网络，并讨论了潜在的潜在机制和该领域的公开问题。
DNA methylation is established by DNA methyltransferases and is a key epigenetic mark. Ten-eleven translocation (TET) proteins are enzymes that oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) and further oxidization products (oxi-mCs), which indirectly promote DNA demethylation. Here, we provide an overview of the effect of TET proteins and altered DNA modification status in T and B cell development and function. We summarize current advances in our understanding of the role of TET proteins and 5hmC in T and B cells in both physiological and pathological contexts. We describe how TET proteins and 5hmC regulate DNA modification, chromatin accessibility, gene expression, and transcriptional networks and discuss potential underlying mechanisms and open questions in the field.