Differential genomic imprinting of major histocompatibility complex class I antigens in the placenta of the rat.
Differential genomic imprinting of major histocompatibility complex class I antigens in the placenta of the rat.
复制标题
大鼠胎盘中主要组织相容性复合物 I 类抗原的差异基因组印记。
DOI：
10.1095/biolreprod48.5.977
复制
发表时间：
1993
影响因子：
3.6
通讯作者：
Gill3rd,TJ
中科院分区：
文献类型：
--
作者：
Kanbour-Shakir,A;Kunz,HW;Gill3rd,TJ
RTI。大鼠主要组织相容性复合体（MHC）中的A和Pa（I类）基因座在胎盘中具有基因组印记，因为仅表达父系来源的抗原。以确定RTI是否。E（I类）基因座，其定义了MHC相对RT的末端。A基因组印记在胎盘中，研究了两种不同类型的杂交：DA（A 'E-）和WF（AUEu）近交系的所有可能的交配组合以及R16（A' E-）、R33（A 'EU）和R34（A' E-）同源重组系的各种交配。结果表明，Eu位点未被印迹。因此，基因组印记可以是不同的两个内源基因座的一部分，一个多基因家族的紧密连锁不平衡。E”印迹的缺乏不是由于位点是单态的，因为单态的Pa位点是印迹的，并且它最可能不是由于它与印迹的RT 1的距离。A和Pa基因座（0.4cM）。我们认为，控制印迹可能在于物理结构的DNA接近印迹位点。
The RTI. A and Pa (class I) loci in the major histocompatibility complex (MHC) of the rat are genomically imprinted in the placenta, since only the paternally derived antigens are expressed. To determine whether the RTI. E (class I) locus, which defines the end of the MHC opposite RT. A, is genomically imprinted in the placenta, two different types of crosses were studied: all possible mating combinations of the DA (A'E-) and WF (AUEu) inbred strains and various matings of the R16 (A'E-), R33 (A'EU), and R34 (A'E-) congenic recombinant strains. The results showed that the Eu locus was not imprinted. Thus, genomic imprinting can be different at two endogenous loci that are part of a multigene family in tight-linkage disequilibrium. The lack of E" imprinting is not due to the locus' being monomorphic, since the monomorphic Pa locus is imprinted, and it is most probably not due to its distance from the imprinted RT1. A and Pa loci (0.4 cM). We suggest that the control of the imprinting may lie in the physical structure of the DNA proximate to the imprinted locus.