Sesame Seed Lignans and γ-Tocopherol Act Synergistically to Produce Vitamin E Activity in Rats
Sesame Seed Lignans and γ-Tocopherol Act Synergistically to Produce Vitamin E Activity in Rats
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芝麻木脂素和 γ-生育酚协同作用，在大鼠体内产生维生素 E 活性
DOI：
10.1093/jn/122.12.2440
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发表时间：
1992
影响因子：
4.2
通讯作者：
M. Namiki
中科院分区：
文献类型：
--
作者：
K. Yamashita;Y. Nohara;K. Katayama;M. Namiki
在两个实验中检查了仅含有γ-生育酚的芝麻种子的维生素E活性，γ-生育酚是一种维生素E活性仅等于α-生育酚的6-16%的化合物。在第一个实验中，各组大鼠喂食四种饮食：不含维生素E的对照饮食、含α-生育酚的饮食、含γ-生育酚的饮食和含芝麻的饮食。红细胞溶血、血浆丙酮酸激酶活性、血浆和肝脏中过氧化物的变化作为维生素E活性的指标进行了检查。芝麻籽饮食具有较高的维生素E活性，而γ-生育酚饮食中的维生素E活性较低。在血浆和肝脏中，仅在α-生育酚喂食组中发现高浓度的α-生育酚，仅在芝麻籽喂食组中发现高浓度的γ-生育酚，γ-生育酚喂食组肝脏中的γ-生育酚量可忽略不计。在第二个实验中，测试了两种含有芝麻木脂素（芝麻胺酚或芝麻素）和γ-生育酚的饮食。两个芝麻木脂素喂养组的结果与实验1中芝麻种子喂养组中观察到的结果相当。这些实验表明，芝麻籽中的γ-生育酚通过与芝麻籽木脂素的协同相互作用发挥与α-生育酚相等的维生素E活性。
Vitamin E activity of sesame seed, which contains only gamma-tocopherol, a compound that has vitamin E activity equal to only 6-16% that of alpha-tocopherol, was examined in two experiments. In the first experiment, groups of rats were fed four diets: vitamin E-free control diet, alpha-tocopherol-containing diet, gamma-tocopherol-containing diet and sesame seed-containing diet. Changes in red blood cell hemolysis, plasma pyruvate kinase activity, and peroxides in plasma and liver, as indices of vitamin E activity, were examined. The sesame seed diet has high vitamin E activity, whereas this activity was low in the gamma-tocopherol diet. In plasma and liver, alpha-tocopherol was found in high concentration only in the alpha-tocopherol-fed group, and gamma-tocopherol was found in high concentration only in the sesame seed-fed group, with negligible amounts of gamma-tocopherol in liver of the gamma-tocopherol-fed group. In the second experiment, two diets containing sesame lignan (sesaminol or sesamin) and gamma-tocopherol were tested. Results in both of the sesame lignan-fed groups were comparable to those observed in the sesame seed-fed group in Experiment 1. These experiments indicate that gamma-tocopherol in sesame seed exerts vitamin E activity equal to that of alpha-tocopherol through a synergistic interaction with sesame seed lignans.