Choroid plexus in the central nervous system: Biology and physiopathology
Choroid plexus in the central nervous system: Biology and physiopathology
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DOI：
10.1093/jnen/59.7.561
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发表时间：
2000-07-01
影响因子：
3.2
通讯作者：
Ghersi-Egea, JF
中科院分区：
文献类型：
--
作者：
Strazielle, N;Ghersi-Egea, JF
脉络丛（CP）位于大脑的脑室系统中，并形成血液和中枢神经系统（CNS）之间的界面之一。它们由负责脑脊液分泌的紧密上皮组成，其包围含有可渗透毛细血管和淋巴谱系细胞的松散结缔核心。根据其在2个循环液室之间的独特定位，CP上皮参与许多交换过程，这些交换过程要么为大脑提供营养物质和激素，要么从大脑中清除有害化合物和代谢物。脉络丛还参与神经体液脑调节和神经免疫相互作用，从而在维持脑内环境稳定方面做出巨大贡献。除了这些生理功能外，脉络丛在病理过程中的意义也越来越多地被记录。在这篇综述中，我们专注于一些新的方面的CP功能有关的大脑发育，神经-体液信息的传输，脑/免疫系统的相互作用，脑老化，和大脑的药物毒理学。
Choroid plexuses (CPs) are localized in the ventricular system of the brain and form one of the interfaces between the blood and the central nervous system (CNS). They are composed of a tight epithelium responsible for cerebrospinal fluid secretion, which encloses a loose connective core containing permeable capillaries and cells of the lymphoid lineage. In accordance with its peculiar localization between 2 circulating fluid compartments, the CP epithelium is involved in numerous exchange processes that either supply the brain with nutrients and hormones, or clear deleterious compounds and metabolites from the brain. Choroid plexuses also participate in neurohumoral brain modulation and neuroimmune interactions, thereby contributing greatly in maintaining brain homeostasis. Besides these physiological functions, the implication of choroid plexuses in pathological processes is increasingly documented. In this review, we focus on some of the novel aspects of CP functions in relation to brain development, transfer of neuro-humoral information, brain/immune system interactions, brain aging, and cerebral pharmaco-toxicology.