Striatal creatine and glutamate/glutamine in attention-deficit/hyperactivity disorder
Striatal creatine and glutamate/glutamine in attention-deficit/hyperactivity disorder
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DOI：
10.1089/cap.2006.0008
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发表时间：
2007-02-01
影响因子：
1.9
通讯作者：
Schmidtl, Matthias H.
中科院分区：
文献类型：
--
作者：
Carrey, Normand J.;MacMaster, Frank P.;Schmidtl, Matthias H.
目的：多巴胺能前额叶-纹状体通路先前已被牵连在注意力缺陷/多动障碍（ADHD）的神经生物学中。我们使用短回波质子磁共振波谱（1H-MRS）检查谷氨酸在前额叶皮层，左纹状体，并作为对照区，枕叶。方法：13个治疗初治ADHD儿童和10个健康对照组参加。所有患者均为6至11岁的男性。12 ADHD受试者进行了扫描后8周的treatment.Results：纹状体谷氨酸，谷氨酸/谷氨酰胺（Glx）和肌酸浓度更大的ADHD受试者在基线相比，控制。只有纹状体肌酸，而不是谷氨酸或Glx，减少兴奋剂治疗后的ADHD患者。两组之间没有显着差异，注意到在其余的纹状体代谢物或任何枕叶或前额叶皮质metabolites.Conclusions：这些研究结果提供了初步证据的纹状体肌酸/acetamatergic失调多动症。
Objective: The glutamatergic prefrontal-striatal pathway has been implicated previously in the neurobiology of attention-deficit/hyperactivity disorder (ADHD). We used short echo proton magnetic resonance spectroscopy (1H-MRS) to examine glutamate in the prefrontal cortex, left striatum, and, as a control area, the occipital lobe.Method: Thirteen treatment-naive ADHD children and 10 healthy comparison subjects participated. All were males between the ages of 6 to 11 years of age. Twelve ADHD subjects were scanned after 8 weeks of treatment.Results: Striatal glutamate, glutamate/glutamine (Glx) and creatine concentrations were greater in the ADHD subjects at baseline as compared to controls. Only striatal creatine, not glutamate or Glx, was reduced after stimulant treatment in the ADHD patients. No significant differences between groups were noted in the remainder of the striatal metabolites or any of the occipital lobe or prefrontal cortex metabolites.Conclusions: These findings provide initial evidence of a striatal creatine/glutamatergic dysregulation in ADHD.