Lipid nanocapsules for dermal application: A comparative study of lipid-based versus polymer-based nanocarriers
Lipid nanocapsules for dermal application: A comparative study of lipid-based versus polymer-based nanocarriers
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DOI：
10.1016/j.ejpb.2011.04.009
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发表时间：
2011-09-01
影响因子：
4.9
通讯作者：
Lamprecht, Alf
中科院分区：
文献类型：
--
作者：
Abdel-Mottaleb, Mona M. A.;Neumann, Dirk;Lamprecht, Alf
脂质纳米胶囊（LNC）是一种胶体载体，可为许多药物物质和多种给药途径提供控释特性和改善的生物利用度。然而，它们以前没有被探索用于透皮应用。在这里，我们使用布洛芬作为模型药物研究LNC作为透皮给药系统的行为。与其他脂质纳米载体如固体脂质纳米颗粒（SLN）和纳米结构脂质载体（NLC）和聚合物纳米载体进行了比较。发现LNC可使布洛芬的通量速率增加21.9 +/- 0.5，而在药物溶液的情况下为5.8 +/- 0.4 μ g/cm（2）h。SLN和NLC的通量率相似，平均值分别为22.9 +/- 0.5和22.5 +/- 2.0 μ g/cm（2）h。另一方面，与聚合物纳米颗粒的比较表明，相同粒径的聚合物基载体具有较低的渗透增强效果，通量率为10.62 +/- 1.84 μ g/cm（2）h。与LNC相比，聚合物载体在皮肤中的蓄积量高四倍，是SLN和NLC蓄积量的两倍。这些结果表明，LNC可以被认为是有效的SLN和NLC的经皮给药，而聚合物纳米颗粒更适合于局部药物输送到皮肤。(C)2011 Elsevier B. V.保留所有权利。
Lipid nanocapsules (LNC) are colloidal carriers providing controlled release profiles and improved bio-availability for many drug substances and diverse administration routes. However, they have not been explored before for transdermal application. Here, we study the behavior of LNC as a transdermal drug delivery system using ibuprofen as a model drug. A comparison to other lipid nanocarriers such as solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) and polymeric nanocarriers has been made. It was found that LNC could increase the flux rate of ibuprofen 21.9 +/- 0.5 compared to 5.8 +/- 0.4 mu g/cm(2) h in case of drug solution. Similar flux rates were obtained for SLN and NLC with average values of 22.9 +/- 0.5 and 22.5 +/- 2.0 mu g/cm(2) h, respectively. On the other side, comparison to polymeric nanoparticles showed that the polymer-based carriers of the same particle size had lower permeation-enhancing effect with a flux rate of 10.62 +/- 1.84 mu g/cm(2) h. Polymeric carriers had fourfold higher accumulation in the skin compared to that of the LNC and twice the accumulation of SLN and NLC. These results would suggest that the LNC can be considered as efficient as SLN and NLC for the transdermal drug delivery while polymeric nanoparticles are more suitable for localized drug delivery to the skin. (C) 2011 Elsevier B.V. All rights reserved.