Elevated Plasma Soluble CD14 Levels Correlate with the Monocyte Response Status During Hantaan Virus Infection in Humans.
Elevated Plasma Soluble CD14 Levels Correlate with the Monocyte Response Status During Hantaan Virus Infection in Humans.
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DOI：
10.1089/vim.2015.0040
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发表时间：
2015-10
期刊：
影响因子：
2.2
通讯作者：
TangKang;ZhangChunmei;ZhangYusi;Zhangyun;ZhuangRan;JinBoquan;Maying
中科院分区：
文献类型：
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作者：
TangKang;ZhangChunmei;ZhangYusi;Zhangyun;ZhuangRan;JinBoquan;Maying
Abstract Hantaan virus (HTNV) infection can cause severe hemorrhagic fever with renal syndrome (HFRS) in humans. CD14, a pattern recognition receptor recognizing lipopolysaccharide, is highly expressed on monocytes and can be shed as soluble CD14 (sCD14) upon monocyte activation. To understand the role of sCD14 in HFRS, the sCD14 plasma concentrations from 45 HFRS patients were quantified, and the relationships between the plasma sCD14 level and the monocyte response status and clinical parameters were analyzed. The plasma sCD14 levels were significantly higher in the HFRS patients and they correlated with monocyte expansion and activation, which were characterized by increased blood monocyte counts, the proportion of CD14++CD16+ intermediate monocytes, as well as elevated plasma tumor necrosis factor-α (TNF-α) and soluble CD163 (sCD163) levels. Additionally, the high plasma sCD14 levels positively correlated with white blood cell counts and blood urea nitrogen levels and negatively correlated with platel...
