Narrowband ultraviolet B phototherapy to clear and maintain clearance in patients with mycosis fungoides
Narrowband ultraviolet B phototherapy to clear and maintain clearance in patients with mycosis fungoides
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DOI：
10.1016/j.jaad.2005.03.012
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发表时间：
2005-08-01
影响因子：
13.8
通讯作者：
Kolemen, F
中科院分区：
文献类型：
--
作者：
Boztepe, G;Sahin, S;Kolemen, F
背景和目的：一些报告发现窄谱紫外线 B (UVB) 光疗对早期蕈样肉芽肿 (MF) 有益。尽管停止治疗后的快速复发似乎会干扰其疗效，但文献中并未讨论延长无复发间隔的最佳维持方案。本研究的目的是回顾我们在 MF 患者中使用窄带 UVB 的经验。患者和方法：对 14 名接受窄带 UVB 的疾病阶段 IA-IB (n = 10) 和 IIA (n = 4) 经组织学证实的 MF 患者（10 名男性，4 名女性；年龄范围，28-74 岁）的所有可用数据进行回顾性评估。结果：11 例患者获得完全缓解 (CR)。平均 25 次治疗后有 14 例 (78%)。 CR 后，11 名患者中的 10 名接受了平均 22 个月（范围 7-43 个月）的随访；一名患者在 CR 后立即失访。八名患者完成了推荐的维持窄带 UVB 治疗方案。中位维持时间为 18 个月（范围 12-30 个月）。维持期间无患者复发。平均无复发持续时间为 26.0 +/- 9.9 个月。局限性：研究组中的患者数量相对较少。结论：本研究提供的证据表明，窄谱 UVB 可能是 IA 期和 113 期以及 IIA 期 MF 患者的有效治疗选择。结果表明，CR 后使用维持光疗是一种合理的方法，可能会延长 MF 的缓解持续时间。
Background and purpose: Narrowband ultraviolet B (UVB) phototherapy for early-stage mycosis fungoides (MF) has been found to he beneficial in some reports. Although rapid recurrences after discontintiation of therapy appear to interfere with its efficacy, optimal maintenance schedules for prolonged relapse-free intervals are not discussed in the literature. The purpose of this study was to review Our experience with narrowband UVB in patients with MF.Patients and Methods: All available data that belong to 14 patients (10 male, 4 female; age range, 28-74 years) with histologically proven MF, at disease stages IA-IB (n = 10) and IIA (n = 4) who received narrowband UVB were retrospectively evaluated.Results: Complete response (CR) was achieved in 11 of 14 cases (78%) after a mean of 25 treatments. Ten of 11 patients were followed tip for a median of 22 months (range, 7-43 months) after CR; one patient was lost to follow-up immediately after CR. Eight patients completed the recommended maintenance narrowband UVB therapy protocol. The median duration of maintenance was 18 months (range, 12-30 months). No patient had relapse during maintenance. Mean relapse-free duration was 26.0 +/- 9.9 months.Limitations: The number of patients in the study group was relatively few.Conclusion: This Study provides evidence that narrowband UVB might be an efficient treatment option for MF patients at stages IA and 113, as well as at stage IIA. Results Suggest that using maintenance phototherapy after CR is a logical approach, which may prolong the duration of remission in MF.