DISRUPTIVE NOCTURNAL BEHAVIOR IN PARKINSONS-DISEASE AND ALZHEIMERS-DISEASE
DISRUPTIVE NOCTURNAL BEHAVIOR IN PARKINSONS-DISEASE AND ALZHEIMERS-DISEASE
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DOI：
10.1177/089198879500800206
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发表时间：
1995-04-01
影响因子：
2.6
通讯作者：
HUGHES, M
中科院分区：
文献类型：
--
作者：
BLIWISE, DL;WATTS, RL;HUGHES, M
破坏性的夜间行为，通常被称为日落，是大多数形式的痴呆症中常见的临床问题。这项研究比较了阿尔茨海默病（AD）和帕金森病（PD）患者的破坏性夜间行为。问卷资料收集自60名AD和48名PD照顾者。受访者被要求记录一天中的典型时间，当七种破坏性行为中的任何一种在他们的病人身上被证明时，如果有的话。计算了两个分数：（1）日落得分（夜间破坏性行为的数量，范围0-7），和（2）总得分（与时间无关的破坏性行为的数量，范围0-7）。结果表明，PD患者比AD患者更容易表现出破坏性的夜间行为。抗帕金森病药物的剂量、时间或年数与PD患者组的夜间破坏性行为无关。这些发现提出了这样的可能性：PD患者的日落可能是基底神经节内多巴胺能耗尽或涉及脑干中胆碱能、血清素能和/或去甲肾上腺素能系统的其他异常的表现。
Disruptive nocturnal behavior, often referred to as sundowning, is a commonly encountered clinical problem in most forms of dementia. This study compared disruptive nocturnal behavior in patients with Alzheimer's disease (AD) and Parkinson's disease (PD). Questionnaire data were collected from 60 AD and 48 PD caregivers. Respondents were asked to record the typical time of day when any of seven disruptive behaviors were evidenced in their patients, if at all. Two scores were computed: (1) a sundowning score (number of nocturnal disruptive behaviors, range 0-7), and (2) a total score (number of disruptive behaviors without regard to time, range 0-7). Results indicated PD patients were more likely than AD patients to exhibit disruptive nocturnal behavior. The dose, timing, or number of years on antiparkinsonian medication were not related to nocturnal disruptive behavior within the PD patient group. These findings raise the possibility that sundowning in PD patients may be a manifestation of dopaminergic depletion within the basal ganglia or other abnormalities involving the cholinergic, serotoninergic and/or noradrenergic systems in the brainstem.