Multiple comparisons in over-the-counter drug clinical trials with both positive and placebo controls.
Multiple comparisons in over-the-counter drug clinical trials with both positive and placebo controls.
复制标题
非处方药临床试验中与阳性对照和安慰剂对照的多重比较。
DOI：
--
复制
发表时间：
1991
影响因子：
2
通讯作者：
Timothy C. Heeren
中科院分区：
文献类型：
--
作者：
R. D’Agostino;Timothy C. Heeren
使用方差分析技术评价非处方药的疗效常常误用多个比较程序。将安慰剂对照和既定药物作为阳性对照的研究尤其容易出现这些问题。最常见的错误包括使用不控制实验类型I错误率的程序，通常是邓肯程序或某些版本的多重t检验。这些程序控制了比较明智的I型错误率，但缺乏重要的实验明智的错误控制。本文的目的是澄清在涉及安慰剂和阳性对照的非处方药研究中进行多重比较程序后进行方差分析所涉及的问题。
Evaluations of the efficacy of over-the-counter drugs using ANOVA techniques often misuse multiple comparison procedures. Studies that involve both a placebo control and established drugs as positive controls are especially prone to these problems. The most common mistake involves using a procedure which does not control the experimentwise type I error rate, usually the Duncan procedure or some version of multiple t tests. These procedures control comparisonwise type I error rate, but lack the important experimentwise error control. The purpose of this paper is to clarify the issues involved in performing ANOVA followed by a multiple comparison procedure for over-the-counter drug studies involving both placebo and positive controls.