The distribution of H19HP haplotypes in Asian populations
The distribution of H19HP haplotypes in Asian populations
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H19HP单倍型在亚洲人群中的分布
DOI：
10.1016/j.fsigss.2011.09.033
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发表时间：
2011
期刊：
影响因子：
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通讯作者：
Nori Nakayashiki
中科院分区：
文献类型：
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作者：
庚徹;小谷賢太郎;朝尾隆文;堀井健;内藤裕一・米田穣・力石嘉人・大河内直彦;Nori Nakayashiki
H19HP是一个常染色体单倍型系统，由23个在种族群体中具有高度多样性的SNP组成，也是一个父母起源的可检测到的多态性。本研究调查了H19HP单倍型在7个亚洲人群(日本、中国、韩国、蒙古、缅甸、泰国和土耳其)中的分布。2、6、10、15和17 5种单倍型在每个群体中普遍存在且占主导地位。检测到了几个新的群体特异性序列，包括单倍型21。有趣的是，单倍型19，即带有一个SNP的单倍型17(Rs76162918)，几乎只在来自四个地区的日本受试者中观察到，平均频率约为8%。因此，这一系统可能是一种有用的法医工具，不仅用于人类身份识别，而且还用于确定种族，特别是对日本人。
An autosomal haplotype system, H19HP, is composed of 23 SNPs with high diversity in ethnic groups, and also a parent-of-origin detectable polymorphism. In this study, the distribution of H19HP haplotypes in seven Asian populations (Japanese, Chinese, Korean, Mongolian, Burmese, Thai and Turk) was investigated. Five haplotypes, 2, 6, 10, 15 and 17, were commonly and dominantly observed in each population. Several new population-specific sequences, including haplotype 21, were detected. Interestingly, haplotype 19, which is haplotype 17 with one SNP (rs76162918), was observed almost exclusively in Japanese subjects from four areas, with a significant frequency of about 8% on average. This system might therefore be useful as a forensic tool, not only for human identification purposes, but also for determining ethnicity, especially for Japanese subjects.