Antibiotic Resistance in the Neonatal Intensive Care Unit.
Antibiotic Resistance in the Neonatal Intensive Care Unit.
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DOI：
10.1542/neo.20-3-e135
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发表时间：
2019-03-01
期刊：
影响因子：
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通讯作者：
Cantey, Joseph B
中科院分区：
文献类型：
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作者：
Ramirez, Carina B;Cantey, Joseph B
抗生素耐药细菌是NICU中日益严重的问题。无效的经验性抗生素治疗与发病率和死亡率的风险增加有关。对多种抗微生物剂具有耐药性的生物体（多重耐药生物体）尤其成问题。如果不遵守感染控制措施，这些微生物可能会传播给婴儿，或者它们可能是通过抗生素暴露产生的。因此，细致的感染预防，包括手卫生，监测文化，接触预防措施和选择性去殖民化和抗生素管理是重要的战略，以尽量减少耐药性在新生儿重症监护病房。
Antibiotic-resistant bacteria are an increasing problem in the NICU. Ineffective empiric antibiotic therapy is associated with increased risk for morbidity and mortality. Organisms that are resistant to multiple antimicrobial agents (multidrug-resistant organisms) are particularly problematic. These organisms may be transmitted to infants if infection control practices are not adhered to, or they may be created by antibiotic exposure. Therefore, meticulous infection prevention-including hand hygiene, surveillance cultures, contact precautions, and selective decolonization-and antibiotic stewardship are important strategies to minimize drug resistance in the NICU.