Transient ischemic attacks before ischemic stroke:: Preconditioning the human brain?: A multicenter magnetic resonance imaging study
Transient ischemic attacks before ischemic stroke:: Preconditioning the human brain?: A multicenter magnetic resonance imaging study
复制标题
DOI：
10.1161/01.str.0000115767.17923.6a
复制
发表时间：
2004-03-01
期刊：
影响因子：
8.3
通讯作者：
Weih, M
中科院分区：
文献类型：
--
作者：
Wegener, S;Gottschalk, B;Weih, M
背景和目的-我们调查是否短暂性脑缺血发作（TIA）中风前可以诱导耐受性，通过提高阈值的组织易损性在human brain.Methods -65例首次缺血性领土中风患者接受扩散和灌注加权MRI在12小时内的症状发作。流行病学和临床数据，病变体积在T2，表观扩散系数（ADC）地图和灌注地图，脑血流量和脑血容量值进行了比较，患者和无前驱TIA.结果-尽管相似的大小和严重程度的灌注不足，最初的扩散病变往往较小，最终梗死体积显着减少（最终T2：9.1 [四分位距，19.7] vs 36.5 [91.2] mL; P = 0.014），有TIA病史的患者（n = 16）。这与轻度的临床defictions.Conclusions -TIA对ADC和T2病变大小的有益影响表明人脑中存在内源性神经保护作用。
Background and Purpose - We investigated whether transient ischemic attacks ( TIAs) before stroke can induce tolerance by raising the threshold of tissue vulnerability in the human brain.Methods - Sixty-five patients with first-ever ischemic territorial stroke received diffusion- and perfusion-weighted MRI within 12 hours of symptom onset. Epidemiological and clinical data, lesion volumes in T2, apparent diffusion coefficient ( ADC) maps and perfusion maps, and cerebral blood flow and cerebral blood volume values were compared between patients with and without a prodromal TIA.Results - Despite similar size and severity of the perfusion deficit, initial diffusion lesions tended to be smaller and final infarct volumes were significantly reduced ( final T2: 9.1 [interquartile range, 19.7] versus 36.5 [91.2] mL; P = 0.014) in patients with a history of TIA ( n = 16). This was associated with milder clinical deficits.Conclusions - The beneficial effect of TIAs on lesion size in ADC and T2 suggests the existence of endogenous neuroprotection in the human brain.