Imaging of multistep human hepatocarcinogenesis by CT during intra-arterial contrast injection
Imaging of multistep human hepatocarcinogenesis by CT during intra-arterial contrast injection
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DOI：
10.1159/000078478
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发表时间：
2004-01-01
期刊：
影响因子：
4.6
通讯作者：
Matsuia, O
中科院分区：
文献类型：
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作者：
Matsuia, O
肝硬化肝脏中可见各种类型的肝细胞结节。在这些结节中，现在考虑两种类型的人类肝癌发生。一种是从头发生肝癌，另一种是从高级别不典型增生结节(DN)、高级别DN伴分化良好的HCC病灶和明显的HCC逐步发展。根据我们的动脉门静脉造影（CTAP）CT、肝动脉造影（CTHA）CT和组织学研究，随着结节恶性程度的升高，包括正常门静脉（结节内门脉供应）和肝动脉（通过正常肝动脉供应结节内动脉）在内的门静脉减少。另一方面，异常动脉（通过新形成的异常动脉供应结节内动脉）逐渐增加。因此，我们可以根据结节内的血供来估计结节的恶性程度。了解这种血液供应模式对于早期 HCC 的早期检测、表征和治疗非常重要。我们还发现结节的预后与血液供应模式之间存在密切相关性。版权所有 (C) 2004 S. Karger AG，巴塞尔。
Various types of hepatocellular nodules are seen in cirrhotic livers. In these nodules, two types of human hepatocarcinogenesis are now considered. One is de novo hepatocarcinogenesis and the other is the stepwise development from high-grade dysplastic nodule (DN), high-grade DN with well-differentiated HCC foci, and overt HCC. According to our analysis by CT during arterial portography (CTAP) and CT during hepatic arteriography (CTHA) and histological study, in accordance with the elevation of the grade of malignancy of the nodules, the portal tract including normal portal vein (intranodular portal supply) and hepatic artery (intranodular arterial supply through normal hepatic arteries) are decreased. On the other hand, abnormal artery (intranodular arterial supply through newly formed abnormal arteries) gradually increases. Therefore, we can estimate the grade of malignacy of the nodules from intranodular blood supply. To know this blood supply pattern is important for the early detection, characterization and treatment of early stage HCCs. We also revealed that there was a close correlation between the prognosis of the nodules and the blood supply patterns. Copyright (C) 2004 S. Karger AG, Basel.