Regulation of Morphological and Functional Aspects of Sexual Dimorphism in the Brain
Regulation of Morphological and Functional Aspects of Sexual Dimorphism in the Brain
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DOI：
10.5772/intechopen.97470
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发表时间：
2021-04
期刊：
影响因子：
--
通讯作者：
C. Orikasa
中科院分区：
文献类型：
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作者：
C. Orikasa
成年脑的性二型性调节啮齿动物的性依赖功能，包括生殖和神经内分泌活动。在雌性和雄性啮齿动物的关键围产期期间，它由性类固醇激素决定。性类固醇作用于大脑中的每个核受体，并控制不同的生理和神经内分泌功能和行为。大脑的几个区域显示出明显的形态性别差异，这些差异涉及其生理功能。这篇评论主要关注大脑中性别依赖性差异的作用，以及它们在动物模型中的重要功能。特别是，最近有趣的数据有关的多样性神经元功能和性二态性进行了讨论。
Sexual dimorphism of the adult brain regulates sex-dependent functions including reproductive and neuroendocrine activities in rodents. It is determined by sex steroid hormones during a critical perinatal period in female and male rodents. Sex steroids act on each nuclear receptor in the brain and control different physiological and neuroendocrine functions and behaviors. Several regions of the brain show evident morphological sex differences that are involved in their physiological functions. This review addresses and focuses largely on the role of sex-dependent differences in the brain, and their crucial functions in animal models. Particularly, recent intriguing data concerning the diversity of neuronal functions and sexual dimorphism are discussed.