Marine Natural Products in Clinical Use.
Marine Natural Products in Clinical Use.
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在其他植物、动物和微生物来源的天然产物中，海洋天然产物是有效且有前途的药物来源。迄今为止，已有20种来自海洋的药物投入临床使用。大多数批准的海洋化合物具有抗肿瘤作用，但有些也用于治疗慢性神经性疼痛、肝素过量、作为半抗原和疫苗载体，以及在饮食中补充 omega-3 脂肪酸。海洋药物具有不同的结构特征和作用机制。过去几十年来，批准用于临床的海洋药物数量大幅增加，这可能归因于世界各地实验室对海洋化合物的研究不断增加。在本手稿中，我们全面研究了所有已成功应用于临床的海洋药物。研究人员和临床医生希望发现更多的药物，因为大量海洋天然化合物正在临床前和临床研究中进行研究。
Marine natural products are potent and promising sources of drugs among other natural products of plant, animal, and microbial origin. To date, 20 drugs from marine sources are in clinical use. Most approved marine compounds are antineoplastic, but some are also used for chronic neuropathic pain, for heparin overdosage, as haptens and vaccine carriers, and for omega-3 fatty-acid supplementation in the diet. Marine drugs have diverse structural characteristics and mechanisms of action. A considerable increase in the number of marine drugs approved for clinical use has occurred in the past few decades, which may be attributed to increasing research on marine compounds in laboratories across the world. In the present manuscript, we comprehensively studied all marine drugs that have been successfully used in the clinic. Researchers and clinicians are hopeful to discover many more drugs, as a large number of marine natural compounds are being investigated in preclinical and clinical studies.
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影响因子：
1.2
作者：
Altmann, Karl-Heinz
通讯作者：
Altmann, Karl-Heinz
影响因子：
11.2
作者：
Cai, Jie;Damaraju, Vijaya L.;Gros, Philippe
通讯作者：
Gros, Philippe
DOI：
10.1358/dot.2020.56.4.3127026
发表时间：
2020-04
期刊：
Drugs of today (Barcelona, Spain : 1998)
影响因子：
--
作者：
Amaya ML;Jimeno A;Kamdar M
通讯作者：
Kamdar M
影响因子：
1.1
作者：
BLAJCHMAN, MA
通讯作者：
BLAJCHMAN, MA
DOI：
10.1039/jr9560002388
发表时间：
1956-01-01
期刊：
JOURNAL OF THE CHEMICAL SOCIETY
影响因子：
--
作者：
BROWN, DM;TODD, A;VARADARAJAN, S
通讯作者：
VARADARAJAN, S