BEHAVIORAL-EFFECTS OF MORPHINE IN MICE - ROLE OF EXPERIMENTAL HOUSING
BEHAVIORAL-EFFECTS OF MORPHINE IN MICE - ROLE OF EXPERIMENTAL HOUSING
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DOI：
10.1016/0091-3057(89)90327-4
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发表时间：
1989-10-01
影响因子：
3.6
通讯作者：
CASTELLANO, C
中科院分区：
文献类型：
--
作者：
DAMATO, FR;CASTELLANO, C
在孤立的胆怯瑞士小鼠中评估吗啡的行为影响，并与非攻击性分组受试者服用吗啡后观察到的结果进行比较。为此目的，在 4 分钟的测试中观察注射了盐水和吗啡（0.5、1.0、2.5 和 5.0 mg/kg，IP）的孤立胆怯和非攻击性分组的小鼠与社会伙伴的互动。结果得出三个要点：（a）在基础条件下，与社交小鼠相比，胆怯的小鼠的进攻性矛盾行为明显不那么明显，而防御性矛盾行为（以及所有逃跑行为）则明显更明显； (b) 2.5 mg/kg 吗啡会增加胆怯小鼠的攻击性矛盾行为并减少防御性矛盾行为； (c) 在社交小鼠中，吗啡（2.5 毫克/千克）治疗增加了防御性矛盾行为和蹲伏时间。结果表明，吗啡的行为影响取决于个体的状态，并根据该阿片类药物的抗情绪特性进行解释。
Behavioral effects of morphine were assessed in isolated-timid Swiss mice, and were compared with those observed following morphine administration in nonaggressive-grouped subjects. For this purpose saline- and morphine- (0.5, 1.0, 2.5, and 5.0 mg/kg, IP) injected isolated-timid and nonaggressive-grouped mice interacting with a social partner were observed during a 4-min test. Three main points emerged from the results: (a) in basal conditions, compared with social mice, in timid mice the offensive ambivalent behaviors were significantly less pronounced, while the defensive ambivalent behaviors (and all flight behaviors) were significantly more evident; (b) 2.5 mg/kg of morphine increased offensive and decreased defensive ambivalent behaviors in timid mice; (c) in social mice morphine (2.5 mg/kg) treatment increased defensive ambivalent behaviors and time spent in crouch. The results, which show that the behavioral effects of morphine depend on the state of the individual, are interpreted on the basis of the antiemotional properties of this opiate.