Extent of medial temporal resection on outcome from anterior temporal lobectomy: a randomized prospective study.
Extent of medial temporal resection on outcome from anterior temporal lobectomy: a randomized prospective study.
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DOI：
10.1227/00006123-199511000-00019
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发表时间：
1995-11
期刊：
影响因子：
4.8
通讯作者：
A. Wyler;B. Hermann;G. Somes;D. Spencer;D. Roberts;J. Engel
中科院分区：
文献类型：
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作者：
A. Wyler;B. Hermann;G. Somes;D. Spencer;D. Roberts;J. Engel
我们报告了一项前瞻性、随机、盲法临床试验，比较了两组患者前颞叶切除术的癫痫发作和神经心理学结果。一组（n = 34）接受了大脑脚前缘后方的海马切除术（部分海马切除术）。在另一组（n = 36）中，海马体被进一步切除至上丘水平（全海马切除术）。各组间外侧皮质切除量相同。患者有神经心理学发病率。术后 1 年，与部分海马切除组相比，全海马切除组的癫痫发作结果具有统计学意义（69% 与 38% 无癫痫发作），并且对首次癫痫发作时间的检查（生存分析）显示，与全海马切除术相关的结果显着优越。更广泛的海马切除并没有增加神经心理学发病率。
WE REPORT A prospective, randomized, blinded clinical trial comparing seizure and neuropsychological outcomes from anterior temporal lobectomies between two groups of patients. One group (n = 34) underwent hippocampal resection posteriorly to the anterior edge of the cerebral peduncle (partial hippocampectomy). In the other group (n = 36), the hippocampus was removed further to the level of the superior colliculus (total hippocampectomy). The amount of lateral cortical resection was the same between groups. Patients were and neuropsychological morbidity. At 1 year postoperatively, the total hippocampectomy group had a statistically superior seizure outcome compared with the partial hippocampectomy group (69 versus 38% seizure-free), and examination of time to first seizure (survival analysis) revealed significantly superior outcomes associated with total hippocampectomy. There was no increased neuropsychological morbidity associated with the more extensive hippocampal resection.