Biologic indicators of cadmium nephrotoxicity in persons with low-level cadmium exposure.
Biologic indicators of cadmium nephrotoxicity in persons with low-level cadmium exposure.
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DOI：
10.1289/ehp.8454163
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发表时间：
1984-03
影响因子：
10.4
通讯作者：
Nogawa K
中科院分区：
文献类型：
--
作者：
Nogawa K
本文对33例Itai-Itai患者、17例疑似患者、235例镉接触者和41例非镉接触者的尿异常与肾功能的关系进行了研究。晚期慢性镉中毒患者的尿液检查结果与肾功能之间有很高的相关性，复相关系数达0.73 ~ 0.86。轻中度镉中毒患者尿β 2-微球蛋白与肾功能及年龄密切相关。结论：在中重度慢性镉中毒患者中，尿蛋白、糖尿和低分子量蛋白尿是肾功能损害的良好指标。轻、中度患者尿β 2-微球蛋白与肾功能损害关系密切。
The relationship between abnormal urinary findings and renal function was investigated for 33 Itai-Itai patients, 17 suspected patients, 235 subjects exposed to Cd and 41 subjects not exposed to Cd pollution. High correlation coefficients were observed between urinary findings and renal function in advanced cases of chronic cadmium poisoning, and multiple correlation coefficients between them are as high as 0.73 to 0.86. beta 2-microglobulin in urine also correlated closely with renal function and age in slight to moderate cases of cadmium poisoning. It is concluded that urinary findings such as proteinuria, glucosuria and low molecular weight proteinuria are good indicators of renal dysfunction in moderate to severe cases of chronic cadmium poisoning. In slight to moderate cases beta 2-microglobulin in urine has a close relation with renal dysfunction.