Nanomedicine, Volume Iia: Biocompatibility
Nanomedicine, Volume Iia: Biocompatibility
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发表时间：
2003-09
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通讯作者：
R. Freitas
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作者：
R. Freitas
兼容性最广泛地指的是两个不同的系统或类别的东西混合或放在一起而不会产生不利的结果的适合性。更具体地说，医疗纳米机器人设备的安全性、有效性和实用性将严重依赖于它们与人体器官、组织、细胞和生化系统的生物相容性。经典的生物相容性往往集中在身体的免疫和血栓形成反应的外来物质放置在it.In本卷中，我们扩大了纳米医学生物相容性的定义，包括所有的机械，生理，免疫，细胞学和生物化学反应的人体引入医疗nanodevices，无论是颗粒状纳米或块状纳米的形式。也就是说，医疗纳米设备可以包括大剂量的独立的微米尺寸的个体纳米机器人，或者替代地可以包括宏观尺度的纳米器官（纳米机器人器官），其组装为固体物体或由数万亿个较小的人工细胞或停靠在体内的纳米机器人构建。我们还讨论了被放置在人体内的纳米机器人的影响。
Compatibility most broadly refers to the suitability of two distinct systems or classes of things to be mixed or taken together without unfavorable results. More specifically, the safety, effectiveness, and utility of medical nanorobotic devices will critically depend upon their biocompatibility with human organs, tissues, cells, and biochemical systems. Classical biocompatibility has often focused on the immunological and thrombogenic reactions of the body to foreign substances placed within it. In this Volume, we broaden the definition of nanomedical biocompatibility to include all of the mechanical, physiological, immunological, cytological, and biochemical responses of the human body to the introduction of medical nanodevices, whether particulate or bulk in form. That is, medical nanodevices may include large doses of independent micron-sized individual nanorobots, or alternatively may include macroscale nanoorgans (nanorobotic organs) assembled either as solid objects or built up from trillions of smaller artificial cells or docked nanorobots inside the body. We also discuss the effects on the nanorobot of being placed inside the human body.