Characterization of Death in Neonatal Encephalopathy in the Hypothermia Era.
Characterization of Death in Neonatal Encephalopathy in the Hypothermia Era.
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DOI：
10.1177/0883073816681904
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发表时间：
2017-03
影响因子：
1.9
通讯作者：
Glass HC
中科院分区：
文献类型：
--
作者：
Lemmon ME;Boss RD;Bonifacio SL;Foster-Barber A;Barkovich AJ;Glass HC
We aimed to characterize the circumstances of death in encephalopathic neonates treated with therapeutic hypothermia. In this cohort study, we identified patients who died after or during treatment with therapeutic hypothermia between 2007–2014. We categorized circumstance of death using an established paradigm. Thirty-one of 229 patients died (14%) at a median of 3 days of life. Most who died were severely encephalopathic on examination (90%) and had severely abnormal electroencephalographic (EEG) findings (87%). All those who had MRIs (n=13) had evidence of moderate-severe brain injury; 6 had near-total brain injury. Cooling was discontinued prematurely in 61% of patients. Most patients (90%) were physiologically stable at the time of death; 81% died following elective extubation for quality of life considerations. Three patients (10%) died following removal of artificial hydration and nutrition. Characterization of death in additional cohorts is needed to identify differences in decision making practices over time and between centers.
