Soft and MRI Compatible Neural Electrodes from Carbon Nanotube Fibers
Soft and MRI Compatible Neural Electrodes from Carbon Nanotube Fibers
复制标题
由碳纳米管纤维制成的软且 MRI 兼容的神经电极
DOI：
10.1021/acs.nanolett.8b04456
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发表时间：
2019-03-01
期刊：
影响因子：
10.8
通讯作者：
Duan, Xiaojie
中科院分区：
文献类型：
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作者：
Lu, Linlin;Fu, Xuefeng;Duan, Xiaojie
软质和磁共振成像（MRI）兼容的神经电极能够实现稳定的长期电生理测量以及整个大脑的解剖或功能MRI研究，而不会干扰MRI图像。这些特性对于许多研究都很重要，从功能性MRI信号的基础神经生理学研究到治疗性脑深部电刺激的慢性神经调节效应研究。在这里，我们开发软和MRI兼容的神经电极使用碳纳米管（CNT）纤维的直径从20 μ m下降到5 μ m。在7.0 T MRI扫描仪下，CNT纤维电极表现出优异的界面电化学性能，并且比PtIr电极大大减少了MRI伪影。通过航天飞机辅助植入策略，我们表明软碳纳米管纤维电极可以精确瞄准特定大脑区域并记录高质量的单单位神经信号。值得注意的是，它们能够连续检测和分离大鼠的单个神经元单位长达4-5个月，而无需电极重新定位，与其坚硬的金属对应物相比，大大减少了大脑炎症反应。此外，我们表明，由于其高拉伸强度，CNT纤维电极可以可控地回缩后插入，这提供了一种有效和方便的方式来做多深度记录或潜在地选择具有特定响应特性的细胞。长期记录稳定性和MRI兼容性，以及它们的小尺寸，为基础和应用神经科学研究提供了CNT纤维电极独特的研究能力。
Soft and magnetic resonance imaging (MRI) compatible neural electrodes enable stable chronic electro-physiological measurements and anatomical or functional MRI studies of the entire brain without electrode interference with MRI images. These properties are important for many studies, ranging from a fundamental neurophysiological study of functional MRI signals to a chronic neuromodulatory effect investigation of therapeutic deep brain stimulation. Here we develop soft and MRI compatible neural electrodes using carbon nanotube (CNT) fibers with a diameter from 20 mu m down to 5 mu m. The CNT fiber electrodes demonstrate excellent interfacial electrochemical properties and greatly reduced MRI artifacts than PtIr electrodes under a 7.0 T MRI scanner. With a shuttle-assisted implantation strategy, we show that the soft CNT fiber electrodes can precisely target specific brain regions and record high-quality single-unit neural signals. Significantly, they are capable of continuously detecting and isolating single neuronal units from rats for up to 4-5 months without electrode repositioning, with greatly reduced brain inflammatory responses as compared to their stiff metal counterparts. In addition, we show that due to their high tensile strength, the CNT fiber electrodes can be retracted controllably postinsertion, which provides an effective and convenient way to do multidepth recording or potentially selecting cells with particular response properties. The chronic recording stability and MRI compatibility, together with their small size, provide the CNT fiber electrodes unique research capabilities for both basic and applied neuroscience studies.