Pain in AQP4-IgG-positive and MOG-IgG-positive neuromyelitis optica spectrum disorders.
Pain in AQP4-IgG-positive and MOG-IgG-positive neuromyelitis optica spectrum disorders.
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DOI：
10.1177/2055217318796684
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发表时间：
2018-07
影响因子：
--
通讯作者：
Paul F
中科院分区：
文献类型：
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作者：
Asseyer S;Schmidt F;Chien C;Scheel M;Ruprecht K;Bellmann-Strobl J;Brandt AU;Paul F
疼痛是水通道蛋白-4免疫球蛋白- g阳性视神经脊髓炎谱系障碍（AQP4-IgG-pos）的常见症状。NMOSD)。具有临床NMOSD表型（MOG-IgG-pos）的髓鞘-少突胶质细胞-糖蛋白-免疫球蛋白-g自身免疫的疼痛数据。NMOSD)很少。本文的目的是研究MOG-IgG-pos的疼痛。NMOSD AQP4-IgG-pos。NMOSD和未检测AQP4/MOG-IgG的NMOSD （AQP4/MOG-IgG-neg）。NMOSD)。49 MOG-IgG-pos。（n = 14）， AQP4-IgG-pos。（n = 29）和AQP4/ mog - igg -阴性。（n = 6） NMOSD患者被纳入一项正在进行的观察性研究的横断面基线分析。我们通过磁共振成像确定脊髓病变，通过painDETECT和McGill疼痛问卷评估疼痛，通过简短健康调查评估生活质量，通过Beck抑郁量表评估抑郁。十二MOG-IgG-pos。NMOSD患者（86%），24例AQP4-IgG-pos。NMOSD患者（83%），AQP4/ mog - igg均为阴性。NMOSD患者（100%）出现疼痛。MOG-IgG-pos。NMOSD患者以神经性疼痛和头痛为主；AQP4-IgG-pos。和AQP4 / MOG-IgG-neg。NMOSD患者以神经性疼痛为主。MOG-IgG-pos患者脊髓炎病史较少。NMOSD高于AQP4-IgG-pos。NMOSD病人。疼痛影响所有患者的生活质量。36%的疼痛患者接受了止痛药治疗；没有一个人没有痛苦。疼痛是MOG-IgG-pos患者的常见症状。NMOSD和在AQP4-IgG-pos中同样重要。和AQP4 / MOG-IgG-neg。NMOSD。尽管疼痛对生活质量有影响，但药物并不能充分缓解疼痛。
Pain is a frequent symptom in aquaporin-4-immunoglobulin-G-positive neuromyelitis optica spectrum disorders (AQP4-IgG-pos. NMOSD). Data on pain in myelin-oligodendrocyte-glycoprotein-immunoglobulin-G autoimmunity with a clinical NMOSD phenotype (MOG-IgG-pos. NMOSD) are scarce. The objective of this paper is to investigate pain in MOG-IgG-pos. NMOSD, AQP4-IgG-pos. NMOSD and NMOSD without AQP4/MOG-IgG detection (AQP4/MOG-IgG-neg. NMOSD). Forty-nine MOG-IgG-pos. (n = 14), AQP4-IgG-pos. (n = 29) and AQP4/MOG-IgG-neg. (n = 6) NMOSD patients were included in this cross-sectional baseline analysis from an ongoing observational study. We identified spinal cord lesions on magnetic resonance imaging, assessed pain by the painDETECT and McGill Pain questionnaires, quality of life by Short Form Health Survey, and depression by Beck Depression Inventory. Twelve MOG-IgG-pos. NMOSD patients (86%), 24 AQP4-IgG-pos. NMOSD patients (83%), and all AQP4/MOG-IgG-neg. NMOSD patients (100%) suffered from pain. MOG-IgG-pos. NMOSD patients had mostly neuropathic pain and headache; AQP4-IgG-pos. and AQP4/MOG-IgG-neg. NMOSD patients had mostly neuropathic pain. A history of myelitis was less frequent in MOG-IgG-pos. NMOSD than in AQP4-IgG-pos. NMOSD patients. Pain influenced quality of life in all patients. Thirty-six percent of patients with pain received pain medication; none of them were free of pain. Pain is a frequent symptom of patients with MOG-IgG-pos. NMOSD and is as important as in AQP4-IgG-pos. and AQP4/MOG-IgG-neg. NMOSD. Despite its impact on quality of life, pain is insufficiently alleviated by medication.