Escherichia coli constructs expressing human or porcine enterotoxins induce identical diarrheal diseases in a piglet infection model.
Escherichia coli constructs expressing human or porcine enterotoxins induce identical diarrheal diseases in a piglet infection model.
复制标题
表达人或猪肠毒素的大肠杆菌构建体在仔猪感染模型中诱导相同的腹泻疾病。
DOI：
10.1128/aem.00893-08
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发表时间：
2008
影响因子：
4.4
通讯作者：
Francis,DavidH
中科院分区：
文献类型：
--
作者：
Zhang,Weiping;Robertson,DonaldC;Zhang,Chengxian;Bai,Wei;Zhao,Mojun;Francis,DavidH
为了建立一种用于研究腹泻疾病和开发疫苗的仔猪模型，我们用构建成表达猪987P(F6)菌毛的同源大肠埃希氏菌和一种热不稳定或热稳定的肠毒素来测试临床结果。当仔猪接种表达人或猪肠道毒素的重组体时，会出现相同的腹泻疾病。
To develop a piglet model for studying diarrheal disease and developing vaccines, we challenged gnotobiotic piglets with isogenicEscherichia colistrains constructed to express porcine 987P(F6) fimbriae and a heat-labile or a heat-stable enterotoxin to examine clinical outcomes. Piglets developed identical diarrheal diseases when inoculated with constructs expressing human or porcine enterotoxins.