Functional development of the visual system in normal and protein deprived rats. I. Persistent changes in light-induced cortical evoked response.
Functional development of the visual system in normal and protein deprived rats. I. Persistent changes in light-induced cortical evoked response.
复制标题
正常和蛋白质缺乏大鼠视觉系统的功能发育。
DOI：
10.1111/j.1748-1716.1984.tb07424.x
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
S. Andersson
中科院分区：
文献类型：
--
作者：
A. Sjöström;N. Conradi;S. Andersson
在对正常和蛋白质剥夺大鼠视觉诱发反应（VER）发育的研究中，发现了持续潜伏期差异的迹象，由于这种差异与以前的报道不同，因此特别注意比较对照和蛋白质剥夺成年大鼠。从妊娠开始前两周至检查，通过饲喂与对照大鼠饮食相比蛋白质含量减少50%的饮食诱导蛋白质剥夺。依赖于实验变量的lavelet和复杂性的VER说明了一个定义良好的实验情况的需要。成年蛋白质剥夺大鼠表现出显着更长的潜伏期，以发病和前三个峰的VER和改变的复杂性的反应。这表明，所观察到的变化是由于蛋白质剥夺对早期大脑发育的影响，因为这项研究和以前的研究表明，在发育中的年轻大鼠有类似的变化。本报告和以往报告的调查结果之间的差异可能是由于营养不良程度和其他实验条件的差异。
During an investigation focused on development of visual evoked responses (VER) in normal and protein deprived rats indications of persisting latency differences were found. Since such differences are in variance with previous reports special attention was paid to compare control and protein deprived adult rats. Protein deprivation was induced by feeding rats a diet with 50% reduction in protein content compared with control rat diet from two weeks before onset of gestation until examination. Dependence on experimental variables of latencies and complexity of the VER illustrated the need of a well defined experimental situation. Adult protein deprived rats showed significantly longer latencies to onset and to the first three peaks of the VER and an altered complexity of the response. It is suggested that the observed alterations result from effects of the protein deprivation on early brain development since this and previous studies have shown similar alterations in developing young rats. The divergence in findings between the present and previous reports may be explained by differences in degree of malnutrition and in other experimental conditions.