Vaccination history and risk of childhood leukaemia.
Vaccination history and risk of childhood leukaemia.
复制标题
疫苗接种史和儿童白血病的风险。
DOI：
10.1093/ije/dyi113
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Buffler,PatriciaA
中科院分区：
文献类型：
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作者：
Ma,Xiaomei;Does,MoniqueB;Metayer,Catherine;Russo,Carolyn;Wong,Alan;Buffler,PatriciaA
BackgroundPrevious studies on vaccination and childhood leukaemia generated unacceptable results.MethodsIn the北方加州儿童白血病研究，一个病例对照研究与事件的情况下，匹配的出生证明控制，详细的书面疫苗接种记录被收集。共有323例0-14岁的诊断和409名对照被纳入本分析。在参考日期（病例的诊断日期和匹配对照的相应日期）对所有疫苗接种进行删失。进行条件logistic回归分析，调整潜在的混杂因素。感兴趣的一个主要变量是管理（剂量）的各种类型的vaccine.ResultsVaccinations对白喉，百日咳，破伤风，脊髓灰质炎，麻疹，腮腺炎，风疹的数量与白血病的风险无关。每剂流感嗜血杆菌B型（HiB）疫苗的优势比为0.81（95%CI 0.68-0.96）。与接种两剂或更少剂量Hib疫苗的儿童相比，接种三剂或更多剂量的儿童患白血病的风险显著降低（比值比= 0.55，95%置信区间0.32-0.94）。收到的B型肝炎疫苗的剂量数与白血病risk. ConclusionsHi B疫苗接种与儿童白血病的风险降低。未来需要进行详细的暴露评估和大样本量的研究，以进一步解决疫苗接种在儿童白血病病因中的作用。
BackgroundPrevious studies on vaccination and childhood leukaemia generated inconsistent results.MethodsIn the Northern California Childhood Leukaemia Study, a case–control study with incident cases and matched birth certificate controls, detailed written vaccination records were collected. A total of 323 cases aged 0–14 years at diagnosis and 409 controls were included in this analysis. All vaccinations were censored on the reference date (date of diagnosis for cases and the corresponding date for matched controls). Conditional logistic regression analysis was conducted, adjusting for potential confounding factors. A primary variable of interest is the number of administrations (doses) of various types of vaccines.ResultsVaccinations against diphtheria, pertussis, tetanus, poliomyelitis, measles, mumps, and rubella were not associated with the risk of leukaemia. The odds ratio for each dose ofHaemophilus influenzaetype b (Hib) vaccine was 0.81 (95% CI 0.68–0.96). Compared with children who received two or fewer doses of Hib vaccine, those who received three or more doses had a significantly reduced risk of childhood leukaemia (odds ratio = 0.55, 95% confidence interval 0.32–0.94). The number of doses of hepatitis B vaccine received was not associated with leukaemia risk.ConclusionsHib vaccination is associated with a reduced risk of childhood leukaemia. Future studies with detailed exposure assessment and large sample sizes are needed to further address the role of vaccinations in the etiology of childhood leukaemia.