Effect of Hydrophilic and Hydrophobic Nanoparticles on the Surface Pressure Response of DPPC Monolayers
Effect of Hydrophilic and Hydrophobic Nanoparticles on the Surface Pressure Response of DPPC Monolayers
复制标题
DOI：
10.1021/jp207713x
复制
发表时间：
2011-11-10
影响因子：
3.7
通讯作者：
Ravera, Francesca
中科院分区：
文献类型：
--
作者：
Guzman, Eduardo;Liggieri, Libero;Ravera, Francesca
研究了肺表面活性物质(LS)的主要成分1，2-二棕榈酰甘油-3-磷胆碱(DPPC)与亲水性二氧化硅(SiO_2)和疏水性炭黑(CB)的朗缪尔单分子膜之间的相互作用。用布儒斯特角显微镜观察了纳米粒子诱导的单层界面结构的变化。结果表明，纳米粒子的加入影响了分子的界面组织，并对其相行为和力学性能产生了重要的影响。与炭黑相比，白炭黑对DPPC相行为的影响更大，但两者都影响DPPC的单层弹性、崩塌条件以及模拟呼吸循环的面积膨胀-压缩表面压力响应的非线性。由于DPPC是肺表面活性物质的主要成分，本文的结果在更广泛的纳米颗粒对肺表面活性物质界面性质影响的研究框架内是相关的。
The study of the interaction between Langmuir monolayers of 1,2-dipalmitoyl-sn-glycerol-3-phosphocholine (DPPC), as the major component of lung surfactant (LS), and nanoparticles of different nature, hydrophilic silica (SiO2) and hydrophobic carbon black (CB), has been carried out by measuring the compression Pi-A isotherms and the response of the surface pressure to harmonic variations of the interfacial area simulating respiratory cycles in a Langmuir trough. The change of the monolayer interfacial structure induced by nanoparticles was monitored by Brewster angle microscopy. The results point out that nanoparticles incorporating into the monolayers influence the interfacial organization of the molecule's and induce important modifications in both the phase behavior and the mechanical properties. Silica has stronger effects on DPPC phase behavior, compared to carbon black, while both affect the monolayer elasticity, the collapse conditions, and the nonlinearity of the surface pressure response to area expansion-compression simulating the respiratory cycles. With DPPC being the major component of pulmonary surfactant, the results here obtained are relevant in the framework of wider studies on the effect of nanoparticles on the pulmonary surfactant interfacial properties.