Macular segmentation with optical coherence tomography
Macular segmentation with optical coherence tomography
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DOI：
10.1167/iovs.04-0335
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发表时间：
2005-06-01
影响因子：
4.4
通讯作者：
Schuman, JS
中科院分区：
文献类型：
--
作者：
Ishikawa, H;Stein, DM;Schuman, JS
目的.为了开发软件算法以在线性黄斑光学相干断层扫描（StratusOCT; Carl Zeiss Meditec，Inc.，都柏林，CA）扫描图像，并测试其在区分正常眼和昏迷眼方面的性能，并与传统的视乳头周围神经纤维层（cpNFL）厚度测量进行比较。定义视网膜内的四层结构：黄斑神经纤维层（mNFL）、视网膜内层复合体（IRC;视网膜神经节细胞[RGC]层+内部丛状层和核层）、视网膜外层复合体（OPL）和视网膜外层复合体（ORC;外核层+感光层）。正常眼和青光眼眼行快速黄斑地图和快速NFL OCT扫描。使用开发的算法分析线性黄斑图像，并将结果与cpNFL厚度测量进行比较。分析了47例受试者（23例正常和24例青光眼）。正常眼mNFL、cpNFL、IRC及视网膜总厚度均显著大于青光眼眼（P
PURPOSE. To develop a software algorithm to perform automated segmentation of retinal layer structures on linear macular optical coherence tomography (StratusOCT; Carl Zeiss Meditec, Inc., Dublin, CA) scan images and to test its performance in discriminating normal from glaucomatous eyes in comparison with conventional circumpapillary nerve fiber layer (cpNFL) thickness measurement.METHODS. Four layer structures within the retina were defined: the macular nerve fiber layer (mNFL), the inner retinal complex (IRC; retinal ganglion cell [RGC] layer + inner plexiform and nuclear layers), outer plexiform layer (OPL), and outer retinal complex (ORC; outer nuclear layer + photoreceptor layer). Normal and glaucomatous eyes underwent fast macular map and fast NFL OCT scans. Linear macular images were analyzed using the developed algorithm, and the results were compared with the cpNFL thickness measurement.RESULTS. Forty-seven subjects (23 normal and 24 with glaucoma) were analyzed. mNFL, cpNFL, IRC, and the total retinal thicknesses were significantly greater in normal than in glaucomatous eyes (P