Reliability of cancer family history reported by parents in a case-control study of childhood leukemia
Reliability of cancer family history reported by parents in a case-control study of childhood leukemia
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DOI：
10.1007/s10552-012-0045-4
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发表时间：
2012-10-01
影响因子：
2.3
通讯作者：
Doucette, Kimberley
中科院分区：
文献类型：
--
作者：
Infante-Rivard, Claire;Roncarolo, Federico;Doucette, Kimberley
旨在调查急性淋巴细胞白血病（ALL）儿童父母和健康对照儿童父母报告的癌症家族史的可靠性。根据基线时阳性或阴性癌症家族史、病例对照状态以及受访者性别（母亲或父亲），总共选择了 301 名父母。使用相同的调查问卷将基线答复与第二次访谈的答复进行比较。使用总体一致性比例、Cohen's kappa 和 Cronbach's alpha 来衡量可靠性；还使用逻辑回归模型来评估病例对照状态作为因变量对总体一致性的作用。访谈之间的总体一致性很高，并且病例（85％）和对照（86％）相似；受访者的性别、第一次访谈时的年龄或访谈之间的时间间隔对一致性指标没有一致的影响。根据受访者是否报告其母亲、父亲或兄弟姐妹，一致性指标没有显着差异。该研究表明，患有白血病的儿童的年轻父母和健康对照儿童的父母报告家族史的可靠性非常高。
To investigate the reliability of family history of cancer reported by parents of children with acute lymphoblastic leukemia (ALL) and parents of healthy control children.A total of 301 parents were selected based on positive or negative family history of cancer at baseline, case-control status, and gender of the respondent (mother or father). Baseline responses were compared with responses at the second interview using the same questionnaire. Reliability was measured using proportion of overall agreement, Cohen's kappa, and Cronbach's alpha; a logistic regression model was also used to assess the role of the case-control status on overall agreement as the dependent variable.The overall agreement between interviews was high and similar for cases (85 %) and controls (86 %); there were no consistent effects of respondent gender, age at first interview, or time elapsed between interviews on agreement measures. Agreement measures did not materially vary according to whether respondents were reporting about their mothers, fathers, or siblings.The study showed very good reliability of reporting family history among young parents of children affected with leukemia and parents of healthy control children.