A supramolecular multi-block copolymer with a high propensity for alternation
A supramolecular multi-block copolymer with a high propensity for alternation
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DOI：
10.1021/ja064116s
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发表时间：
2006-11-01
影响因子：
15
通讯作者：
Zimmerman, Steven C.
中科院分区：
文献类型：
--
作者：
Park, Taiho;Zimmerman, Steven C.
利用四重氢键作为非共价结合力，生成了交替的多嵌段超分子共聚物。一个区块由两个鸟苷丁基脲（UG）单元组成，连接在三甘醇连接剂或PEG链的末端（MW = 2kd）。另一个区块包含一个2,7-二氨基-1,8-萘啶（DAN）单元在短链二酯连接体的两端或一个100 kD的聚甲基丙烯酸丁酯大分子。UG单元呈现出一个ADDA氢键阵列，与DAN的DAAD阵列互补，它们形成了一个非常强的配合物（Kassoc ~ 5 × 107M-1），而UG和DAN则弱自缔合。这些识别特性允许形成具有高交替倾向的多嵌段超分子聚合物。自组装聚合物结构是可逆形成的，并通过动态光散射（DLS）、1H NMR、粒径排除色谱（SEC）和粘度测定法对其进行了表征。
Alternating, multi-block supramolecular copolymers were created using quadruple hydrogen bonding as the noncovalent binding force. One block consisted of two guanosine butyl urea (UG) units attached at the ends of a triethylene glycol linker or a PEG chain (MW = 2 kD). The other block contained a 2,7-diamido-1,8-naphthyridine (DAN) unit at each end of a short alkane diester linker or a 100 kD poly(butyl methacrylate) macromolecule. The UG unit presents an ADDA hydrogen bonding array that is complementary to the DAAD array of DAN, and these form a very strong complex (Kassoc∼ 5 × 107M-1), whereas UG and DAN weakly self-associate. These recognition properties allowed a multi-block supramolecular polymer to form which exhibits a high propensity for alternation. The self-assembled polymeric structure was shown to be reversibly formed and it was characterized by a combination of dynamic light scattering (DLS),1H NMR, size exclusion chromatography (SEC), and viscometry.