DECREASED PLASMA TRYPTOPHAN LEVELS IN MAJOR DEPRESSION
DECREASED PLASMA TRYPTOPHAN LEVELS IN MAJOR DEPRESSION
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DOI：
10.1016/0165-0327(89)90051-7
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发表时间：
1989-01-01
影响因子：
6.6
通讯作者：
NEWSHOLME, EA
中科院分区：
文献类型：
--
作者：
COWEN, PJ;PARRYBILLINGS, M;NEWSHOLME, EA
12例抑郁症患者血浆总色氨酸显著低于12例正常对照。总色氨酸与中性氨基酸的比例也在抑郁症患者中降低，这表明色氨酸对大脑的可用性可能会降低。抑郁症患者的基础色氨酸浓度与随后对静脉注射色氨酸的神经内分泌反应之间没有相关性。
Total plasma tryptophan was significantly lower in 12 depressed patients than in 12 normal controls. The ratio of total tryptophan to neutral amino acids was also decreased in the depressed patients suggesting that tryptophan availability to the brain might be reduced. There was no correlation between basal tryptophan concentration in the depressed subjects and the subsequent neuroendocrine response to intravenous tryptophan.