Fluoride and calcium-phosphate coated sponges of the magnesium alloy AX30 as bone grafts: a comparative study in rabbits
Fluoride and calcium-phosphate coated sponges of the magnesium alloy AX30 as bone grafts: a comparative study in rabbits
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DOI：
10.1007/s10856-012-4812-2
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发表时间：
2013-02-01
影响因子：
3.7
通讯作者：
Meyer-Lindenberg, Andrea
中科院分区：
文献类型：
--
作者：
Lalk, Mareike;Reifenrath, Janin;Meyer-Lindenberg, Andrea
采用氟化物（MgF2海绵，n = 24，孔隙度为63 +/- a 6%，孔径为394 +/- a 26 μ m）和氟化物和附加磷酸钙涂层（CaP海绵，n = 24，孔隙度为6 +/- a 4%，孔径为109 +/- a 37 μ m）对海绵镁（AX30合金）在兔股骨中的生物相容性和降解进行了6、12和24周的评估。空钻孔（n = 12）作为对照。进行了临床和放射学检查，体内和离体计算机断层扫描和组织学检查。临床两种海绵均耐受良好。x线片和xtreect评估显示骨变化与对照组相当，并有轻度气体形成。CT80对CaP海绵的降解更高，更不均匀。从组织形态学上看，MgF2海绵具有最高的骨和类骨成分，并能很好地融入骨中。组织学上，CaP海绵表现出更多的炎症和较低的血管化。结果表明，MgF2海绵具有更好的生物相容性和生物可降解性。
Biocompatibility and degradation of magnesium sponges (alloy AX30) with a fluoride (MgF2 sponge, n = 24, porosity 63 +/- A 6 %, pore size 394 +/- A 26 mu m) and with a fluoride and additional calcium-phosphate coating (CaP sponge, n = 24, porosity 6 +/- A 4 %, pore size 109 +/- A 37 mu m) were evaluated over 6, 12 and 24 weeks in rabbit femurs. Empty drill holes (n = 12) served as controls. Clinical and radiological examinations, in vivo and ex vivo mu-computed tomographies and histological examinations were performed. Clinically both sponge types were tolerated well. Radiographs and XtremeCT evaluations showed bone changes comparable to controls and mild gas formation. The mu CT80 depicted a higher and more inhomogeneous degradation of the CaP sponges. Histomorphometrically, the MgF2 sponges resulted in the highest bone and osteoid fractions and were integrated superiorly into the bone. Histologically, the CaP sponges showed more inflammation and lower vascularization. MgF2 sponges turned out to be better biocompatible and promising, biodegradable bone replacements.