SYSTEMIC CANDIDIASIS - A STUDY OF 109 FATAL CASES
SYSTEMIC CANDIDIASIS - A STUDY OF 109 FATAL CASES
复制标题
DOI：
10.1097/00006454-198201000-00005
复制
发表时间：
1982-01-01
影响因子：
3.6
通讯作者：
HUGHES, WT
中科院分区：
文献类型：
--
作者：
HUGHES, WT
为了进一步了解受损宿主中系统性念珠菌病的临床特征，在死亡前2个月内对109例死亡病例进行了研究，并进行了完整的尸检。发热、粒细胞减少、恶性肿瘤复发以及抗生素和免疫抑制药物治疗构成了约90%患者的临床特征。88%的患者有一个以上的深部器官受累，不包括消化道和呼吸道的粘膜病变。按最高频率排列的主要器官是肺、脾、肾、肝、心脏和脑。白色念珠菌是91例病例的病原体，其中18例涉及其他念珠菌属。2858份标本的死前培养对诊断的帮助有限。伴随感染常见，通常是死亡原因。
To gain further insight into the clinical features of systemic candidiasis in the compromised host, 109 fatal cases were studied during the 2 months prior to demise and by complete autopsy examination. Fever, granulocytopenia, relapse of the malignancy and therapy with antibiotics and immunosuppressive drugs comprise the clinical profile of approximately 90% of the patients. Eighty-eight percent of the patients had more than one deep organ affected, excluding mucosal lesions of the alimentary and respiratory tracts. Major organs involved in order of highest frequency were the lungs, spleen, kidneys, liver, heart and brain. Candida albicans was the causative agent in 91 cases and other Candida species were implicated in 18 of the cases. Antemortem cultures of 2858 specimens were of limited diagnostic aid. Concomitant infections were frequent and usually the cause of death.