Obesity, diabetes and cognitive deficit: The Framingham Heart Study
Obesity, diabetes and cognitive deficit: The Framingham Heart Study
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DOI：
10.1016/j.neurobiolaging.2005.08.019
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发表时间：
2005-12-01
影响因子：
4.2
通讯作者：
D'Agostino, RB
中科院分区：
文献类型：
--
作者：
Elias, MF;Elias, PK;D'Agostino, RB
目的：确定肥胖对认知表现的独立影响，并检验肥胖与非胰岛素依赖型糖尿病（NIDDM）之间的相互作用。
方法：采用前瞻性设计，弗雷明汉心脏研究的男性（n = 551）和女性（n = 872）参与者被分为肥胖（是/否）、糖尿病（是/否），糖尿病患病年数由18年监测期收集的数据确定。在进行认知测试时，所有受试者均无痴呆、中风和临床诊断的心血管疾病。统计模型根据年龄、教育程度、职业、母语和心血管疾病危险因素进行了调整。体重指数状况（非肥胖或肥胖）以及NIDDM状况（糖尿病/非糖尿病）与多项认知测量中的认知表现相关。
结果：仅在男性中观察到肥胖对认知表现的不良影响。糖尿病患病年数与较差的认知表现相关，但仅在将男性和女性合并分析时如此。未观察到糖尿病以及糖尿病患病年数与肥胖的相互作用。
结论：肥胖的性别特异性结果（糖尿病则无）表明，将它们与认知联系起来的潜在机制可能不同。（c）2005爱思唯尔公司。保留所有权利。
Objective:: To determine the independent effects of obesity on cognitive performance and to examine interactions between obesity and non-insulin dependent diabetes mellitus (NIDDM).Methods:: Using a prospective design, male (n = 551) and female (n = 872) participants of the Framingham Heart Study were classified as obese (yes/no), diabetic (yes/no), and the number of diabetes-years was determined by data collected over an 18-year surveillance period. All subjects were free from dementia, stroke, and clinically diagnosed cardiovascular disease Lip to the time of cognitive testing. Statistical models were adjusted for age, education, occupation, native language, and cardiovascular disease risk factors. Body mass index status (non-obese or obese) and NIDDM status (diabetic/non-diabetic) were related to cognitive performance on multiple cognitive measures.Results:: Adverse effects of obesity on cognitive performance were observed for men only. Diabetes-years related to poorer cognitive performance, but only when men and women were combined for analyses. Neither diabetes nor diabetes-years by obesity interactions were observed.Conclusions:: The gender-specific results for obesity, but not for diabetes, suggests that the underlying mechanisms linking them to cognition may be different. (c) 2005 Elsevier Inc. All rights reserved.