Global patterns of cardia and non-cardia gastric cancer incidence in 2012
Global patterns of cardia and non-cardia gastric cancer incidence in 2012
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DOI：
10.1136/gutjnl-2014-308915
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发表时间：
2015-12-01
期刊：
影响因子：
24.5
通讯作者：
Soerjomataram, I.
中科院分区：
文献类型：
--
作者：
Colquhoun, A.;Arnold, M.;Soerjomataram, I.
目的全球范围内，胃癌的发病率具有显著的国际差异，贲门癌（CGC）和非贲门癌（NCGC）两个主要部位的发病率也具有明显的特点。由于缺乏全球发病率估计的子网站，我们的目的是描述世界范围内的发病模式CGC和NCGC separately.Design使用癌症发病率在五大洲卷X（CI 5X），我们确定的比例CGC和NCGC的国家，性别和年龄组（= 65岁）。将这些推导出的比例应用于GLOBOCAN 2012数据，以估计特定国家的年龄标准化CGC和NCGC发病率（ASR）。结果2012年全球CGC病例数为26万例（ASR 3.3/10万），NCGC病例数为69.1万例（ASR 8.8/10万）。两个胃癌子位点的最高区域发生率均在东亚/东南亚（男性中，CGC和NCGC的ASR分别为8.7和21.7）。在大多数国家，NCGC发生率高于CGC，平均比率为2：1;然而，在NCGC发生率低于全球平均水平的一些人群中，CGC发生率与NCGC发生率相似或高于NCGC发生率。男性的发病率高于女性的两个子网站，但特别是CGC（男女比例为3：1）。结论这项研究首次量化了全球发病模式的CGC和NCGC提供了新的见解，这些癌症的全球负担。提供了具体国家的估计数，但应谨慎解释。这项工作将支持未来对人群的调查。
Objective Globally, gastric cancer incidence shows remarkable international variation and demonstrates distinct characteristics by the two major topographical subsites, cardia (CGC) and non-cardia (NCGC). Because global incidence estimates by subsite are lacking, we aimed to describe the worldwide incidence patterns of CGC and NCGC separately.Design Using Cancer Incidence in Five Continents Volume X (CI5X), we ascertained the proportions of CGC and NCGC by country, sex and age group (= 65 years). These derived proportions were applied to GLOBOCAN 2012 data to estimate country-specific agestandardised CGC and NCGC incidence rates (ASR). Regional proportions were used to estimate rates for countries not included in CI5X.Results According to our estimates, in 2012, there were 260 000 cases of CGC (ASR 3.3 per 100 000) and 691 000 cases of NCGC (ASR 8.8) worldwide. The highest regional rates of both gastric cancer subsites were in Eastern/Southeastern Asia (in men, ASRs: 8.7 and 21.7 for CGC and NCGC, respectively). In most countries NCGC occurred more frequently than CGC with an average ratio of 2: 1; however, in some populations where NCGC incidence rates were lower than the global average, CGC rates were similar or higher than NCGC rates. Men had higher rates than women for both subsites but particularly for CGC (male-to-female ratio 3: 1).Conclusions This study has, for the first time, quantified global incidence patterns of CGC and NCGC providing new insights into the global burden of these cancers. Country-specific estimates are provided; however, these should be interpreted with caution. This work will support future investigations across populations.