The new classifications of ovarian, fallopian tube, and primary peritoneal cancer and their clinical implications
The new classifications of ovarian, fallopian tube, and primary peritoneal cancer and their clinical implications
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DOI：
10.1093/annonc/mdx445
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发表时间：
2017-11-01
影响因子：
50.5
通讯作者：
Kohn, E. C.
中科院分区：
文献类型：
--
作者：
Duska, L. R.;Kohn, E. C.
组织学表征和分期的作用是为癌症分类提供可重复的指标，从而指导最合适的临床护理并产生最稳定可靠的系统以进行前瞻性和回顾性数据分析。恶性卵巢癌/输卵管癌/腹膜癌的组织学和分期分类最近都发生了变化。世界卫生组织赞助了对卵巢癌、输卵管癌和腹膜癌病理学的审查和重新分类，并于 2014 年发布了这些更新。在此过程中，他们对已在浆液性卵巢癌中使用了近十年的两级分级系统进行了编纂。与此同时，FIGO 审查并更新了适用于卵巢癌、输卵管癌和腹膜癌所有组织型的手术分期系统，该系统也于 2014 年发表。在这两种情况下，所做的改变旨在更好地了解疾病，但两者都有重要的优点和缺点。分期的变化使回顾性数据与当前数据的分析变得复杂。尽管在某些方面存在争议，但总体而言，这些变化旨在代表对疾病更好的生物学理解，我们希望这将导致患者护理和定向治疗的改善。
The roles of histologic characterization and staging are to provide reproducible metrics for cancer classification with which to direct the most appropriate clinical care and to yield the most stable reliable system to allow both prospective and retrospective data analysis. Both the histologic and staging classifications of malignant ovarian/tubal/peritoneal cancers have recently changed. The World Health Organization sponsored a review and reclassification of the pathology of cancers of the ovaries, fallopian tubes, and peritoneum, and published these updates in 2014. In so doing, they codified the two-tiered grading system that has been in use in serous ovarian cancers for nearly a decade. In parallel, FIGO reviewed and updated the surgical staging system, applied to all histotypes of ovarian, tubal, and peritoneal cancers, also published in 2014. In both cases, the changes made are meant to encompass a better understanding of disease, but both have important merits and drawbacks. Changes in staging complicate analysis of retrospective data against current data. Though in some aspects controversial, the changes overall are meant to represent a better biologic understanding of disease that we hope will lead to an improvement in patient care and directed therapy.