Allelotyping analysis at chromosome 13q of high-grade prostatic intraepithelial neoplasia and clinically insignificant and significant prostate cancers
Allelotyping analysis at chromosome 13q of high-grade prostatic intraepithelial neoplasia and clinically insignificant and significant prostate cancers
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DOI：
10.1002/pros.20363
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发表时间：
2006-03-01
期刊：
影响因子：
2.8
通讯作者：
Hano, H
中科院分区：
文献类型：
--
作者：
Lu, W;Takahashi, H;Hano, H
背景13 q杂合性丢失（洛）是高分期前列腺癌中最常见的染色体变异之一，但对早期前列腺癌的遗传学改变知之甚少。我们使用5个位于13 q14、21和33的微卫星标记，比较了51例高级别前列腺上皮内瘤变（HGPIN）、21例偶发性前列腺癌（IPC）、31例潜伏性前列腺癌（LPC）和102例临床前列腺癌（CPC）的洛合性缺失（LOH）频率。在HGPIN、IPC、LPC和CPC中，13 q处至少有1个标记的洛缺失频率分别为0%、38%、56%和49%。不同类型前列腺癌之间无统计学显著差异。13q14等位基因丢失在pT4肿瘤中的发生率明显高于早期肿瘤（P = 0.011）。13 q等位基因丢失不仅是前列腺癌转移的重要事件，而且与肿瘤转移的启动有关。
BACKGROUND. Loss of heterozygosity (LOH) at 13q is one of the most common chromosomal alterations in high-stage prostate cancer, yet little is known about genetic changes in earlier-stage prostate cancer.METHODS. We used five microsatellite markers at 13q14, 21, and 33 to compare LOH frequencies in 51 lesions of high-grade prostatic intraepithelial neoplasia (HGPIN), 21 cases of incidental prostate cancers (IPCs), 31 cases of latent prostate cancers (LPCs), and 102 cases of clinical prostate cancers (CPCs).RESULTS. The frequency of LOH at 13q with at least 1 marker was 0%, 38%, 56%, and 49% in HGPIN, IPCs, LPCs, and CPCs, respectively. No statistically significant difference was found between the types of prostate cancer. Allelic loss at 13q14 was significantly more frequent in pT4 tumors than in earlier-stage tumors (P = 0.011).CONCLUSIONS. Allelic loss at 13q is not only an important event in the metastasis of prostate cancer, but also associated with the initiation of the turner.