The origin of extracellular fields and currents--EEG, ECoG, LFP and spikes.
The origin of extracellular fields and currents--EEG, ECoG, LFP and spikes.
复制标题
细胞外田地和电流的起源-EEG，ECOG，LFP和尖峰。
DOI：
10.1038/nrn3241
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发表时间：
2012-05-18
期刊：
影响因子：
--
通讯作者：
Koch C
中科院分区：
文献类型：
--
作者：
Buzsáki G;Anastassiou CA;Koch C
大脑中的神经元活性会引起可以在细胞外培养基中测量的跨膜电流，尽管细胞外信号的主要贡献者是突触跨膜电流，其他来源，包括Na+和Ca2+尖峰门控通道和内在的膜振荡可以实质上塑造细胞外场。以及人类的硬膜下网记录，结合最近开发的数据处理工具和计算建模，可以洞悉神经元的合作行为，它们的平均突触输入及其尖峰输出，并可以提高我们对这些过程如何有助于细胞外的理解信号。
Neuronal activity in the brain gives rise to transmembrane currents that can be measured in the extracellular medium. Although the major contributor of the extracellular signal is the synaptic transmembrane current, other sources — including Na+ and Ca2+ spikes, ionic fluxes through voltage- and ligand-gated channels, and intrinsic membrane oscillations — can substantially shape the extracellular field. High-density recordings of field activity in animals and subdural grid recordings in humans, combined with recently developed data processing tools and computational modelling, can provide insight into the cooperative behaviour of neurons, their average synaptic input and their spiking output, and can increase our understanding of how these processes contribute to the extracellular signal.