The dynamics of chromosome evolution in birds and mammals
The dynamics of chromosome evolution in birds and mammals
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DOI：
10.1038/46555
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发表时间：
1999-11-25
期刊：
影响因子：
64.8
通讯作者：
Waddington, D
中科院分区：
文献类型：
--
作者：
Burt, DW;Bruley, C;Waddington, D
比较作图，比较不同物种中同源基因的位置，是研究基因组进化的有力工具（1）。比较地图显示，哺乳动物染色体变化的速率可以从每百万年一次到十次重排不等（1-4）。根据这些比率，我们预计鸡与人或小鼠相比有84至600个保守片段。在这里，我们建立这些物种之间的比较地图，并估计保守的片段的数量是在这个范围的较低部分。我们的结论是，人类基因组的组织更接近鸡比小鼠，并通过添加比较映射结果从一系列脊椎动物，我们确定了染色体进化的三个可能的阶段。鸡和人类基因组的相对稳定性将使我们能够重建祖先脊椎动物的图谱。
Comparative mapping, which compares the location of homologous genes in different species, is a powerful tool for studying genome evolution(1). Comparative maps suggest that rates of chromosomal change in mammals can vary from one to ten rearrangements per million years(1-4). On the basis of these rates we would expect 84 to 600 conserved segments in a chicken comparison with human or mouse. Here we build comparative maps between these species and estimate that numbers of conserved segments are in the lower part of this range. We conclude that the organization of the human genome is closer to that of the chicken than the mouse and by adding comparative mapping results from a range of vertebrates, we identify three possible phases of chromosome evolution. The relative stability of genomes such as those of the chicken and human will enable the reconstruction of maps of ancestral vertebrates.