Functional indices of vitamin D status and ramifications of vitamin D deficiency
Functional indices of vitamin D status and ramifications of vitamin D deficiency
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DOI：
10.1093/ajcn/80.6.1706s
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发表时间：
2004-12-01
影响因子：
7.1
通讯作者：
Heaney, RP
中科院分区：
文献类型：
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作者：
Heaney, RP
血清 25-羟基维生素 D-3 [25(OH)D-3] 浓度目前被认为是维生素 D 的功能状态指标。有证据表明，血清 25(OH)D-3 浓度 < 80 nmol/L 与钙吸收减少、骨质疏松和骨折风险增加相关。对于典型的老年人来说，需要每天补充约 1300 IU 的摄入量才能达到最佳范围的下限。引用了患者血清 25(OH)D-3 浓度的常规临床测量存在重大问题的证据。血清 25(OH)D-3 浓度测量非常需要标准化并提高其重现性和灵敏度。
Serum 25-hydroxyvitamin D-3 [25(OH)D-3] concentrations are currently recognized as the functional status indicator for vitamin D. Evidence is reviewed that shows that serum 25(OH)D-3 concentrations of < 80 nmol/L are associated with reduced calcium absorption, osteoporosis, and increased fracture risk. For typical older individuals, supplemental oral intakes of similar to1300 IU/d are required to reach the lower end of the optimal range. Evidence of substantial problems in routine clinical measurement of serum 25(OH)D-3 concentrations among patients is cited. There is great need for standardization and improved reproducibility and sensitivity of measurements of serum 25(OH)D-3 concentrations.