Serum IL-36 cytokines levels in type 2 diabetes mellitus patients and their association with obesity, insulin resistance, and inflammation.
Serum IL-36 cytokines levels in type 2 diabetes mellitus patients and their association with obesity, insulin resistance, and inflammation.
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DOI：
10.1002/jcla.23611
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发表时间：
2021-03
影响因子：
2.7
通讯作者：
Li M
中科院分区：
文献类型：
--
作者：
Li Y;Chen S;Zhao T;Li M
白细胞介素（IL）-36细胞因子包括IL-36α、IL-36β、IL-36γ和IL-36 Ra。但对它们在2型糖尿病（T2 DM）中的作用知之甚少。该研究包括40名T2 DM患者和42名健康对照受试者。使用自动生化分析仪、高效液相色谱法和电化学发光免疫分析法进行人体测量和生化测量。通过酶联免疫吸附试验测定循环IL-36α、IL-36γ、IL-36 Ra和IL-17水平。T2 DM患者的血清IL-36α、IL-36γ和IL-17水平显著高于对照组，而T2 DM患者的血清IL-36 Ra水平较低。相关分析显示血清IL-36α与超敏C反应蛋白呈正相关。血清IL-36α与IL-36 Ra呈负相关。血清IL-17与低密度脂蛋白胆固醇呈负相关。本研究表明，T2 DM患者显示IL-36α和IL-36γ表达增加，IL-36 Ra表达降低。此外，炎症细胞因子水平与炎症和血脂水平成正比。我们的研究结果表明，IL-36细胞因子可能是诊断或治疗T2 DM的新靶点。T2 DM患者的IL-36α、IL-36γ和IL-17水平显著高于健康个体。相反，T2 DM患者的血清IL-36 Ra水平显著低于对照受试者。T2 DM患者血清IL-36细胞因子水平与临床生化指标的Pearson相关分析显示，IL-36α与hsCRP呈正相关。IL-17与LDL-C呈负相关。
The interleukin (IL)‐36 cytokines include IL‐36α, IL‐36β, IL‐36γ, and IL‐36Ra. Little was known about their roles in type 2 diabetes mellitus (T2DM). The study included 40 T2DM patients and 42 healthy control subjects. The anthropometric and biochemical measurements were performed using automatic biochemical analyzer, high‐performance liquid chromatography, and electrochemiluminescence immunoassay. Circulating IL‐36α, IL‐36γ, IL‐36Ra, and IL‐17 levels were determined by enzyme‐linked immunosorbent assay. Serum IL‐36α, IL‐36γ, and IL‐17 levels in T2DM patients were significantly higher than those in controls, whereas serum IL‐36Ra levels in T2DM patients were lower. Correlation analysis showed that serum IL‐36α was positively correlated with high sensitivity C‐reactive protein. Serum IL‐36α was negatively correlated with IL‐36Ra. Serum IL‐17 was negatively correlated with low‐density lipoprotein cholesterol. This study demonstrated that T2DM patients displayed increased IL‐36α and IL‐36γ expression and decreased IL‐36Ra expression. Moreover, the inflammatory cytokine levels were directly proportional to the inflammation and blood lipid levels. Our results suggest that IL‐36 cytokines may be a new target for the diagnosis or treatment of T2DM. The IL‐36α, IL‐36γ, and IL‐17 levels in the T2DM patients were significantly higher than those in the healthy individuals. Conversely, the serum IL‐36Ra level of T2DM patients was significantly lower than of the control subjects. Pearson correlation analysis of serum IL‐36 cytokines levels and clinical biochemical parameters in T2DM patients showed that IL‐36α was positively correlated with hsCRP. IL‐17 was negatively correlated with LDL‐C.
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影响因子：
3.2
作者：
Pahk, Kisoo;Kim, Eung Ju;Kim, Sungeun
通讯作者：
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影响因子：
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DOI：
10.3390/molecules201019588
发表时间：
2015-10-27
期刊：
Molecules (Basel, Switzerland)
影响因子：
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DOI：
10.1073/pnas.1121534109
发表时间：
2012-02-21
影响因子：
11.1
作者：
van de Veerdonk, Frank L.;Stoeckman, Angela K.;Dinarello, Charles A.
通讯作者：
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