Associations between ERAP1 polymorphisms and susceptibility to ankylosing spondylitis: a meta-analysis
Associations between ERAP1 polymorphisms and susceptibility to ankylosing spondylitis: a meta-analysis
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ERAP1 多态性与强直性脊柱炎易感性之间的关联：荟萃分析
作者：
Y. Lee;G. Song
本研究的目的是确定内质网氨肽酶1（ERAP 1）的11个多态性是否赋予强直性脊柱炎（AS）的易感性。作者使用固定和随机效应模型对ERAP 1多态性与AS易感性之间的关联进行了荟萃分析。本荟萃分析共纳入19篇文章，其中包括19，902例AS患者和39，750例对照。荟萃分析显示，在所有研究受试者中，AS与rs30187多态性的次要等位基因显著相关（OR = 1.255，95%CI = 1.147-1.373，P = 8.0 × 10−8）。按种族分层，发现该多态性与欧洲患者AS之间存在显著相关性（OR = 1.283，95%CI = 1.237-1.331，P < 1.0 × 10−9）。对rs 27044、rs 10050860、rs 2287987、rs 17482078和rs 26653多态性结果的荟萃分析显示了与rs30187相同的模式。有趣的是，在欧洲和亚洲患者中，rs 27037多态性与AS易感性显著相关。荟萃分析显示，东亚患者中AS与rs 27980和rs 27582多态性的次要等位基因显著相关（OR = 0.904，95% CI = 0.818-0.999，P = 0.047; OR = 0.871，95% CI = 0.772-0.982，P = 0.024）（表2）。然而，这些多态性尚未在欧洲人中进行研究。这项荟萃分析表明ERAP 1多态性与欧洲人和东亚人AS的发生相关。
The aim of this study was to determine whether 11 polymorphisms of endoplasmic reticulum aminopeptidase 1 (ERAP1) confer susceptibility to ankylosing spondylitis (AS). The authors conducted meta-analyses on associations between ERAP1 polymorphisms and AS susceptibility by using fixed and random effects models. A total of 19 articles were included in this meta-analysis, which comprised a total of 19,902 AS patients and 39,750 controls. The meta-analysis revealed a significant association between AS and the minor alleles of the rs30187 polymorphism in all study subjects (OR = 1.255, 95 % CI = 1.147–1.373, P = 8.0 × 10−8). Stratification by ethnicity led to the identification of a significant association between this polymorphism and AS in European patients (OR = 1.283, 95 % CI = 1.237–1.331, P < 1.0 × 10−9). Meta-analyses of the results for the rs27044, rs10050860, rs2287987, rs17482078, and rs26653 polymorphisms showed the same pattern that was found for rs30187. Interestingly, the rs27037 polymorphism was significantly associated with AS susceptibility in both European and Asian patients. Meta-analysis showed a significant association between AS and the minor alleles of the rs27980 and rs27582 polymorphisms in the East Asian patients (OR = 0.904, 95 % CI = 0.818–0.999, P = 0.047; OR = 0.871, 95 % CI = 0.772–0.982, P = 0.024, respectively) (Table 2). However, these polymorphisms have not been studied in Europeans. This meta-analysis shows that the ERAP1 polymorphisms are associated with the development of AS in Europeans and East Asians.
DOI：
10.1073/pnas.0500721102
发表时间：
2005-11-22
影响因子：
11.1
作者：
Chang, SC;Momburg, F;Goldberg, AL
通讯作者：
Goldberg, AL