Baicalin promotes the activation of brown and white adipose tissue through AMPK/PGC1α pathway.
Baicalin promotes the activation of brown and white adipose tissue through AMPK/PGC1α pathway.
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DOI：
10.1016/j.ejphar.2022.174913
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发表时间：
2022-03
影响因子：
5
通讯作者：
Yan-Qiu Zhang;Zhenzhen Zhang;Yiwei Zhang;Leiming Wu;Lu Gao;R. Yao;Yanzhou Zhang
中科院分区：
文献类型：
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作者：
Yan-Qiu Zhang;Zhenzhen Zhang;Yiwei Zhang;Leiming Wu;Lu Gao;R. Yao;Yanzhou Zhang
Obesity occurs when energy intake overtops energy expenditure. Promoting activation of brown adipose tissue (BAT) and white adipose tissue (WAT) has been proven a promising therapeutic strategy for obesity. Baicalin (BAI) has been shown to be protective for various animal models of cardiovascular diseases, such as pulmonary hypertension, atherosclerosis and myocardial hypertrophy. However, whether BAI could stimulate activation of BAT or browning of WAT remains unknown. Here we show that BAI limits weight gaining, ameliorates glucose tolerance, improves cold tolerance and promotes brown-like tissue formation in diet induced obesity mice model. BAI increases the mitochondrial copy number as judged by mtDNA detection. BAI also increases the expression of UCP1 and other classical browning-specific genes in BAT and WAT and cultured C3H10T1/2 adipocytes through a mechanism involving AMPK/PGC1α pathway. Collectively, our study established a role for BAI in regulating energy metabolism, which will provide new idea and theoretical basis for the treatment of obesity.
