Virus infections in patients with AIDS.
Virus infections in patients with AIDS.
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艾滋病患者的病毒感染。
DOI：
10.1016/0035-9203(90)90447-m
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发表时间：
1990
影响因子：
2.2
通讯作者：
Paul D. Griffiths
中科院分区：
文献类型：
--
作者：
Paul D. Griffiths
病毒感染在获得性免疫缺陷综合征（AIDS）患者中很常见。病毒与人类免疫缺陷病毒（HIV）有两种不同的关系：如果第二种病毒利用宿主免疫功能的下降，它们可以是机会，或者它们可以作为辅助因子加速艾滋病的发展速度。作为机会的病毒可能不引起症状或可能危及生命。包括单纯疱疹、水痘带状疱疹、巨细胞病毒和EB病毒在内的几种病毒可以用抗病毒药物治疗。在得出病毒可以作为HIV的辅助因子之前，必须排除其他几种可能的关系，包括机会主义、生活方式的辅助参数和预后标志物。体外试验可能表明哪些病毒是潜在的辅助因子，但明确的证据只能来自仔细定义的患者队列。最近的证据表明，巨细胞病毒可以满足这些标准。
Virus infections are common in patients with acquired immune deficiency syndrome (AIDS). Viruses can have two distinct relationships with human immunodeficiency virus (HIV); they can be opportunists if the second virus takes advantage of decreased immune function in the host or they can act as co-factors to accelerate the rate at which AIDS develops.Viruses acting as opportunists may cause no symptoms or may be life-threatening. Several, including herpes simplex, varicella zoster, cytomegalovirus and Epstein-Barr virus, can be treated with antiviral agents.Before concluding that a virus can act as a co-factor for HIV, several other possible relationships must be excluded including opportunism, co-parameters of lifestyle and prognostic markers. Studiesin vitromay suggest which viruses are potential co-factors but clear evidence can come only from carefully defined cohorts of patients. Recent evidence showing that cytomegalovirus can meet these criteria is presented.
影响因子：
158.5
作者：
DALING, JR;WEISS, NS;COREY, L
通讯作者：
COREY, L