Pharmacokinetics and Pharmacodynamics of Inhaled Glucocorticoids
Pharmacokinetics and Pharmacodynamics of Inhaled Glucocorticoids
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DOI：
10.1080/02770900802569942
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发表时间：
2008-12-01
影响因子：
1.9
通讯作者：
Hochhaus, Gunther
中科院分区：
文献类型：
--
作者：
Padden, Jennifer;Skoner, David;Hochhaus, Gunther
吸入皮质类固醇被广泛用于治疗哮喘。许多不同的类固醇和吸入装置是可用的。不同吸入皮质类固醇的药代动力学和药效学特性可能影响其疗效和安全性。理想吸入皮质类固醇的特性包括低口咽沉积，低口服生物利用度。高肺沉积，长肺停留时间，高受体亲和力，高血浆蛋白结合。以及有效的系统清除。注意这些参数可能有助于临床医生在吸入皮质类固醇治疗个体哮喘患者的安全性和有效性之间取得最佳平衡。
Inhaled corticosteroids are used widely to treat asthma. A number of different steroids and inhalation devices are available. The pharmacokinetic and pharmacodynamic properties of the different inhaled corticosteroids may influence their efficacy and safety profiles. Properties of an ideal inhaled corticosteroid include low oropharyngeal deposition, low oral bioavailability. high lung deposition, long pulmonary residence times, high receptor affinity, high plasma protein binding. and efficient systemic clearance. Attention to these parameters might help clinicians optimally balance between the safety and efficacy of inhaled corticosteroids in treating individual patients with asthma.