Neonatal abstinence syndrome after in utero exposure to selective serotonin Reuptake inhibitors in term infants
Neonatal abstinence syndrome after in utero exposure to selective serotonin Reuptake inhibitors in term infants
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DOI：
10.1001/archpedi.160.2.173
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发表时间：
2006-02-01
影响因子：
--
通讯作者：
Klinger, G
中科院分区：
文献类型：
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作者：
Levison-Castiel, R;Merlob, P;Klinger, G
目的：比较宫内暴露和未暴露于选择性5-羟色胺再摄取抑制剂（SSRIs）的新生儿中新生儿戒断综合征的患病率和临床特征。设计：队列研究。设置：三级护理中心。患者：120名足月婴儿，其中60名在子宫内长期暴露于SSRIs，包括盐酸帕罗西汀、氟西汀、氢溴酸西酞普兰、盐酸舍曲林，主要观察指标：新生儿戒断综合征Finnegan评分：≥ 8分为重度，4 ~ 7分为轻度，0 ~ 3分为正常。所有的婴儿进行了后续的标准化协议，包括重复Finnegan评分评估和心肺功能监测，直到Finnegan score.Results正常化：在60名新生儿暴露于SSRIs在子宫内，8个严重和10个表现出轻度症状的新生儿禁欲综合征。所有未暴露的新生儿的Finnegan评分均正常。在新生儿谁发展严重的症状，最大的平均每日Finnegan评分记录在出生后2天内，虽然最大的个人评分记录长达4天后birth.Conclusions：新生儿禁欲综合征发生在30%的新生儿暴露于SSRIs在子宫内。这些新生儿应在出生后至少监测48小时。长期暴露于SSRIs的长期影响，特别是在出现严重症状的新生儿中，尚未确定。
Objective: To compare the prevalence and clinical characteristics of neonatal abstinence syndrome in neonates exposed and not exposed to selective serotonin reuptake inhibitors (SSRIs) in utero.Design: Cohort study.Setting: Tertiary care center.Patients: One hundred twenty term infants, of whom 60 had prolonged in utero exposure to SSRIs, including paroxetine hydrochloride, fluoxetine, citalopram hydrobromide, sertraline hydrochloride, and venlafaxine hydrochloride.Main Outcome Measures: Neonatal abstinence syndrome was assessed with the Finnegan score as follows: score of 8 or above, severe; score of 4 to 7, mild; and score of 0 to 3, normal. All infants were followed up with a standardized protocol that included repeated Finnegan score assessments and cardiorespiratory monitoring until normalization of the Finnegan score.Results: Of the 60 neonates exposed to SSRIs in utero, 8 showed severe and 10 showed mild symptoms of a neonatal abstinence syndrome. All nonexposed neonates had a normal Finnegan score. In neonates who developed severe symptoms, the maximum mean daily Finnegan scores were recorded within 2 days after birth, although maximum individual scores were recorded as long as 4 days after birth.Conclusions: Neonatal abstinence syndrome occurs in 30% of neonates exposed to SSRIs in utero. These neonates should be monitored for at least 48 hours after birth. The long-term effects of prolonged exposure to SSRIs, particularly in neonates who develop severe symptoms, have yet to be determined.